{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:20:12Z","timestamp":1778498412843,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eccrine porocarcinoma (<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>) is a rare malignant tumor of the eccrine sweat gland. It is a potentially fatal neoplasm that is locally aggressive and commonly recurs. Wide surgical excision has traditionally been the treatment of choice and is curative in approximately 70\u201380% of cases. The disease is metastatic to lymph nodes and distant sites in 20% and 10% of cases, respectively. Metastatic <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> has not shown any great response to adjuvant chemotherapy or radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to evaluate the efficacy of Mohs micrographic surgery (<jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> as an alternative to wide local excision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five patients diagnosed with <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> between 2011 and 2014 at the University of Louisville and treated with <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> were studied. Recurrence\u2010free periods subsequent to the treatment of <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The five patients with <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> treated by <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> remained recurrence\u2010free for a mean of 11\u00a0months (range: 2\u201326\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mohs micrographic surgery is a highly effective treatment for <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>. Given the high rate of recurrence, propensity for lymph node metastases, and the often ineffective options for treating advanced disease, <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> should be considered in the treatment of all cases of <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12997","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T22:14:57Z","timestamp":1437689697000},"page":"1078-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review"],"prefix":"10.1111","volume":"54","author":[{"given":"William James","family":"Tidwell","sequence":"first","affiliation":[{"name":"Division of Dermatology School of Medicine University of Louisville Louisville KY 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