{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:37:44Z","timestamp":1761964664936},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T00:00:00Z","timestamp":1439510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) is one of the most commonly involved sites in the systemic progression of primary cutaneous T\u00a0cell lymphomas (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>s) such as mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>). There is no consensus on the treatment of <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> progression in <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>, but survival of 3\u20136\u00a0months is suggested when methotrexate\u2010based chemotherapy and\/or <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> irradiation is used. Temozolomide is active in earlier stages of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and readily crosses the blood\u2013brain barrier. There are no published data on its use in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients were treated with oral temozolomide (200\u00a0mg\/m<jats:sup>2<\/jats:sup> per day for 5\u00a0d on a 28\u2010day cycle) for <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> progression. Two patients received temozolomide with low\u2010dose <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> irradiation as initial treatment, and two received temozolomide following disease progression after methotrexate\u2010based chemotherapy and <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> irradiation. All patients received dexamethasone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Temozolomide was well tolerated; there were no treatment withdrawals or dose reductions caused by toxicity. Patient\u00a01 had an excellent partial response in pre\u2010irradiated disease. Patient\u00a02 showed disease stabilization following irradiation. Patient\u00a03 showed a complete response after a partial response to irradiation. Patient\u00a04 demonstrated continued stabilization after a partial response to irradiation. Overall survival ranged from 10 to 33\u00a0months. Patient\u00a03 remains alive and symptom\u2010free at 23\u00a0months following treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Temozolomide following low\u2010dose <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> irradiation appears to be well tolerated and effective in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> progression. It may represent a less toxic alternative to chemotherapy containing methotrexate or an option for second\u2010line therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13007","type":"journal-article","created":{"date-parts":[[2015,8,15]],"date-time":"2015-08-15T05:04:52Z","timestamp":1439615092000},"page":"751-756","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Temozolomide for central nervous system involvement in mycosis fungoides"],"prefix":"10.1111","volume":"55","author":[{"given":"Thomas G.","family":"Bird","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology Guy's and St Thomas' National Health Service Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Whittaker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Guy's and St Thomas' National Health Service Foundation Trust London 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