{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:01:13Z","timestamp":1770508873931,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T00:00:00Z","timestamp":1445644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Systemic sclerosis (SS<\/jats:styled-content>c) is a multiorgan autoimmune disorder characterized by sclerosis of the skin and organs as well as the presence of antinuclear autoantibodies. Several types of antinuclear autoantibodies have been described in SS<\/jats:styled-content>c, associated with distinct disease entities and differences in prognosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>The aim of this study was to screen for the presence of antibodies reacting with RNA<\/jats:styled-content> polymerase III<\/jats:styled-content> (anti\u2010RNAP<\/jats:styled-content>3) in a large cohort of patients with SS<\/jats:styled-content>c treated at a tertiary referral center and to evaluate correlations with disease severity.<\/jats:p><\/jats:sec>Results<\/jats:title>Anti\u2010RNAP<\/jats:styled-content>3 antibodies were detected in 11 of 158 patients (7.0%). Eight of the 11 (72.7%) anti\u2010RNAP<\/jats:styled-content>3\u2010positive patients had diffuse cutaneous SS<\/jats:styled-content>c (P<\/jats:italic> < 0.01). A higher modified Rodnan skin score, associated with diffuse SS<\/jats:styled-content>c, correlated with the presence of anti\u2010RNAP<\/jats:styled-content>3 (P<\/jats:italic> < 0.0001). The detection of anti\u2010RNAP<\/jats:styled-content>3 antibodies strongly correlated with the presence of renal involvement (P<\/jats:italic> < 0.0001). The odds ratio of RNAP<\/jats:styled-content>3\u2010positive patients to develop renal involvement was 80.1 (95% CI<\/jats:styled-content> 9.3\u2013690.1).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study demonstrates that the detection of anti\u2010RNAP<\/jats:styled-content>3 antibodies in patients with SS<\/jats:styled-content>c correlates with renal crisis and severe cutaneous involvement. The possibility to detect specific antibodies with a prognostic value can lead to a better risk management of patients with SS<\/jats:styled-content>c.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13032","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T13:47:17Z","timestamp":1445694437000},"page":"882-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["RNA<\/scp> polymerase III autoantibodies may indicate renal and more severe skin involvement in systemic sclerosis"],"prefix":"10.1111","volume":"55","author":[{"given":"Sarah","family":"Terras","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hartenstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology 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