{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:07:51Z","timestamp":1788926871516,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Syringometaplasia is an adaptive, benign, metaplastic cellular process that affects the eccrine ducts and glands in response to a variety of physiological or pathological stimuli. Different subtypes of syringometaplasia have been described, including the squamous, mucinous, and adenomatous types. These metaplastic changes have been reported in association with chemotherapeutic agents, as well as with a variety of skin disorders including multiple infectious, neoplastic, and inflammatory skin diseases. In this review, we attempt to shed light on the different patterns of syringometaplasia, its pathogenesis, the plethora of skin conditions in which it may be observed, and the differential diagnoses that should be considered.<\/jats:p>","DOI":"10.1111\/ijd.13040","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T01:34:28Z","timestamp":1444786468000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Syringometaplasia: variants and underlying mechanisms"],"prefix":"10.1111","volume":"55","author":[{"given":"Ossama","family":"Abbas","sequence":"first","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jag","family":"Bhawan","sequence":"additional","affiliation":[{"name":"Dermatopathology Section Department of Dermatology Boston University School of Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1924.02360270002001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1979.tb01136.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/archderm.1990.01670250079013","article-title":"Eccrine squamous syringometaplasia. A cutaneous sweat gland reaction in the histologic spectrum of \u201cchemotherapy\u2010associated eccrine hidradenitis\u201d and \u201cneutrophilic eccrine hidradenitis\u201d","volume":"126","author":"Hurt M","year":"1990","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb06347.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archderm.1997.03890430089012","article-title":"Chemotherapy\u2010induced eccrine squamous syringometaplasia","volume":"133","author":"Valks R","year":"1997","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199002000-00001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1989.tb00032.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1991.tb01384.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02718.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31822c3bdb"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb01251.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.038"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02123.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00575.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(93)90023-V"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199606000-00004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182036ce7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb00817.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199910000-00016"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200012000-00015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199508000-00019"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00444.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051832"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01488.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12306"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.7.924"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028005223.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00982.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70488-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199804000-00016"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70200-3"},{"key":"e_1_2_7_34_1","first-page":"248","article-title":"Acral mucinous syringometaplasia. A benign cutaneous lesion associated with verrucous hyperplasia","volume":"110","author":"Walker AN","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1990.tb00089.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1991.tb01546.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199312000-00009"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1995.tb01281.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181812729"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181966762"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1985.tb06303.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(03)00289-7"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31817d4c90"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.1.70"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245998"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245997"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00620.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067219100100405"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13040","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:49:30Z","timestamp":1696290570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/ijd.13040"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13040","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]},"assertion":[{"value":"2014-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}