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In Dermatology, there are many reports of privileged localization of cutaneous diseases on injured skin, which therefore represents a typical condition of <jats:italic>lmr<\/jats:italic>. Lately the innovative concept of immunocompromised cutaneous district (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>) has been introduced to explain why a previously injured cutaneous site may become in time a privileged location for the outbreak of opportunistic infections, tumors, and immune reactions. An ample documentation of multifarious disorders (infectious, neoplastic, immune) appearing in <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>s was delineated by Ruocco <jats:italic>et al<\/jats:italic>. in 2009. These cases were grouped according to the clinical settings responsible for the local immune imbalance: regional chronic lymphedema; herpes\u2010infected sites, which feature the well\u2010known Wolf's isotopic response; and otherwise damaged areas, comprising sites of vaccination, ionizing or <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> radiation, thermal burns, and traumas. In the following five years, what was a \u201cnovel\u201d pathogenic concept has been extended to an enlarging variety of clinical conditions. This paper focuses on <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> and the expanding spectrum of this now established pathogenic concept.<\/jats:p>","DOI":"10.1111\/ijd.13086","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T08:43:51Z","timestamp":1445071431000},"page":"135-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Ruocco's immunocompromised cutaneous district"],"prefix":"10.1111","volume":"55","author":[{"given":"Vincenzo","family":"Piccolo","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adone","family":"Baroni","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Second University of Naples Naples 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