{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:10:45Z","timestamp":1769109045515,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increasing evidence has shown that serum micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (miR) levels are useful biomarkers for the diagnosis, prognosis, and therapeutic value in various diseases. Psoriasis is characterized by a specific miR expression profile, with a characteristic miR signature, distinct from that of healthy skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To understand the role of miR\u20101266 in the pathogenesis of psoriasis and to explore if it has the potential as a blood biomarker. We assessed serum miR\u20101266 levels in patients with psoriasis before and after treatment and compared it with controls. In addition, we evaluated the relationship between miR\u20101266 and clinical severity in psoriasis before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>miR\u20101266 was measured using real\u2010time polymerase chain reaction in 35 patients with chronic plaque psoriasis and 35 healthy controls before and after treatment. Moreover, the correlation between miR\u20101266 levels and psoriasis area and severity index score was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum miR\u20101266 levels were considerably higher in patients with psoriasis than in healthy control subjects. Furthermore, miR\u20101266 levels showed a strong positive correlation with psoriasis area and severity index score before and after treatment, having a marked decline with therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>miR\u20101266 may have an important role in the pathogenesis of psoriasis vulgaris. This may presumably have possible future implications on the treatment of this chronic disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13102","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T03:16:53Z","timestamp":1467429413000},"page":"1242-1247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Increased Micro<scp>RNA<\/scp>\u20101266 levels as a biomarker for disease activity in psoriasis vulgaris"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-2186","authenticated-orcid":false,"given":"Neveen Salah","family":"Seifeldin","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen Bendary","family":"El Sayed","sequence":"additional","affiliation":[{"name":"Department of 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