{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:53:38Z","timestamp":1787698418572,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Ethiopia, lymphatic filariasis and podoconiosis are the two neglected tropical diseases planned to be mapped together within the recently launched Ethiopian neglected tropical diseases master plan (2013\u20132015). However, other disorders cause tropical lymphedema, and this report aims to identify clinical epidemiological aspects of limb swelling in northern Ethiopia and to provide an algorithm orienting the clinical diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of patients with lower limb elephantiasis attending the Italian Dermatological Centre of Mekele, Tigray capital city, over a 4\u2010year period (2005\u20132009) were retrospectively analyzed. Nine variables were collected from the charts comprising demographic data, job, origin, literacy, clinical, histopathologic, microscopic, and cultural findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a total of 511 patients, lymphedema resulted from trauma (40.7%), chronic venous insufficiency (12.5%), deep mycoses (10.8%), lymphatic filariasis (9.2%), elephantiasis nostras verrucosa (7.0%), tropical ulcer (6.3%), leprosy (4.9%), recurrent infections (3.1%), podoconiosis (1.8%), tuberculosis (1.0%), malignancy (1.3%), Kaposi's sarcoma (1.0%), leishmaniasis (0.2%), and neurofibromatosis (0.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Advanced\u2010stage elephantiasis, chronic osteomyelitis, and podoconiosis not previously reported in Tigray were observed. Further epidemiological investigation and training programs addressed to healthcare providers at the peripheral level are needed to detect elephantiasis early, prevent disabilities, and improve patients' quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13120","type":"journal-article","created":{"date-parts":[[2015,10,31]],"date-time":"2015-10-31T05:12:15Z","timestamp":1446268335000},"page":"563-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The diagnostic challenge of mapping elephantiasis in the Tigray region of northern Ethiopia"],"prefix":"10.1111","volume":"55","author":[{"given":"Valeska","family":"Padovese","sequence":"first","affiliation":[{"name":"National Institute for Health, Migration and Poverty (NIHMP) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Marrone","sequence":"additional","affiliation":[{"name":"National Institute for Health, Migration and Poverty (NIHMP) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Dassoni","sequence":"additional","affiliation":[{"name":"National Institute for Health, Migration and Poverty (NIHMP) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Vignally","sequence":"additional","affiliation":[{"name":"National Institute for Health, Migration and Poverty (NIHMP) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebre A.","family":"Barnabas","sequence":"additional","affiliation":[{"name":"Tigray Regional Health Bureau Mekele Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Morrone","sequence":"additional","affiliation":[{"name":"Fondazione IME Istituto Mediterraneo di Ematologia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.04.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.2.152"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.08.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.01.023"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.08.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.07099.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/004947550303300410","article-title":"Prevalence of podoconiosis (endemic non\u2010filarial elephantiasis) in Wolaitta, Southern Ethiopia","volume":"32","author":"Destas K","year":"2003","journal-title":"Trop Doct"},{"key":"e_1_2_7_9_1","unstructured":"WHO Media Center Fact sheet N\u00b0102.http:\/\/www.who.int\/mediacentre\/factsheets\/fs102\/en(accessed 14 April 2014)."},{"key":"e_1_2_7_10_1","first-page":"300","article-title":"Bancroftian filariasis in Gambela, Illubabor province, Ethiopia","volume":"25","author":"McConnell E","year":"1973","journal-title":"Trop Geogr Med"},{"key":"e_1_2_7_11_1","first-page":"31","article-title":"A survey of Wuchereria bancrofti in Ethiopia","volume":"14","author":"McConnell E","year":"1976","journal-title":"Ethiop Med J"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60181-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b1686"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60425-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2009.07.021"},{"key":"e_1_2_7_16_1","unstructured":"Federal Democratic Republic of Ethiopia Ministry of Health.National Masterplan for Neglected Tropical Diseases (2013\u20132015).http:\/\/ntdenvision.org\/sites\/default\/files\/docs\/national_ntd_master_plan_ethiopia_2013-2015_1.pdf. 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