{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T23:52:50Z","timestamp":1725061970384},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eccrine porocarcinoma (<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>) is an uncommon malignant neoplasm that originates in the intraepidermal portion of the eccrine sweat duct. Although porocarcinoma is a slow\u2010growing tumor, up to 20% of cases can metastasize to regional lymph nodes, thus increasing mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe the clinical and histopathological features and clinical course of three cases of extensive metastatic <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> diagnosed in our department over the last 10 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All three patients were women aged 89\u201396 years. They had numerous skin tumors on the left leg that were histologically and immunohistochemically diagnosed as metastatic <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>. Only one patient had a history of primary porocarcinoma, which had been excised 6 years earlier. The remaining two patients had a previous lesion diagnosed as squamous cell carcinoma. We treated the patients with palliative radiotherapy and\/or chemotherapy. Only one patient is currently alive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cases of cutaneous and regional metastatic <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> we present occurred in elderly women with major involvement of the left leg. The third case is noteworthy, as the patient presented a long latency period before metastases appeared. Difficulties in the clinical diagnosis \u2013 and occasionally histological diagnosis \u2013 of primary <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> could delay more aggressive treatment, although optimal treatment does not always guarantee a good prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13121","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T02:40:43Z","timestamp":1447468843000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Eccrine porocarcinoma with extensive cutaneous metastases"],"prefix":"10.1111","volume":"55","author":[{"given":"Andrea","family":"Montes\u2010Torres","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario de La Princesa Madrid 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