{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:53:30Z","timestamp":1765886010785},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse cutaneous drug reactions are frequent in hospital settings and are responsible for increased morbidity, mortality, and socioeconomic costs. The objective of this study was to identify high risk factors in hospitalized patients with adverse cutaneous drug reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This descriptive and retrospective study was performed with data from 117 patients admitted to a quaternary hospital over 44 months. We reviewed their epidemiological data, suspected drugs, clinical presentation, histopathological diagnosis, and outcome. Statistical analysis was performed using the chi\u2010squared test with a significance level of 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anticonvulsants were responsible for 23.9% of cases followed by antibiotics (22.2%). In 29% of cases, patients were taking multiple medications that could have triggered their reactions. The most common clinical forms were exanthema (37.6%), drug reaction with eosinophilia and systemic symptoms (<jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>) (14.5%), and Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis (12.8%). Anticonvulsants were associated with severe forms of adverse drug reactions. Most patients (89.7%) presented clinical improvement after treatment. There was a relationship between the use of anticonvulsants and atypical lymphocytes in the dermal infiltrate, as well as the clinical form <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content> and atypical lymphocytes in the dermal infiltrate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of anticonvulsants was a high risk factor for severe clinical forms of drug reactions. The presence of atypical lymphocyte infiltrates in the dermis could indicate the use of anticonvulsants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13126","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T08:40:44Z","timestamp":1451378444000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Adverse cutaneous drug reactions in a single quaternary referral hospital"],"prefix":"10.1111","volume":"55","author":[{"given":"Luciane F.F.","family":"Botelho","sequence":"first","affiliation":[{"name":"Department of Dermatology Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana M.","family":"Porro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milvia M.S.S.","family":"Enokihara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Tomimori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1","article-title":"Report of a WHO meeting","volume":"498","author":"International drug monitoring: the role of national centres","year":"1972","journal-title":"World Health Organ Tech Rep Ser"},{"issue":"1","key":"e_1_2_5_3_1","first-page":"S10","article-title":"Drug allergy. Allergy Asthma","volume":"7","author":"Warrington R","year":"2011","journal-title":"Clin Immunol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000173785.81024.33"},{"key":"e_1_2_5_5_1","volume-title":"Histologic Diagnosis of Inflammatory Skin Diseases: an Algorithmic Method Based on Pattern Analysis","author":"Ackerman AB","year":"1997"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.96191"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04481.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2006.03.010"},{"key":"e_1_2_5_9_1","first-page":"77","article-title":"Rea\u00e7\u00f5es cut\u00e2neas a droga","volume":"67","author":"Oliveira CME","year":"1992","journal-title":"An Bras Dermatol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05584.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.015"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962008000300006"},{"key":"e_1_2_5_13_1","first-page":"165","article-title":"Farmacodermias num hospital geral de Porto Alegre","volume":"59","author":"Weissbluth ML","year":"1984","journal-title":"An Bras Dermatol"},{"key":"e_1_2_5_14_1","unstructured":"OliveiraLAP.Caracter\u00edsticas \u00e9tnicos\u2010raciais da popula\u00e7\u00e3o: um estudo das categorias de classifica\u00e7\u00e3o de cor ou ra\u00e7a. IBGE. Available at:http:\/\/portal.mte.gov.br(accessed 8 November 2013)."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.09.029"},{"key":"e_1_2_5_17_1","first-page":"767","article-title":"Cutaneous adverse drug reactions in hospitalised patients","volume":"51","author":"Lee HY","year":"2010","journal-title":"Singapore Med J"},{"key":"e_1_2_5_18_1","first-page":"125","article-title":"Farmacodermia: aspectos epidemiol\u00f3gicos, tipos cl\u00ednicos e agentes causais","volume":"65","author":"Festa Neto C","year":"1990","journal-title":"An Bras Dermatol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332404"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000300013"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02585.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.039"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.103304"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:15:25Z","timestamp":1695550525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,29]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/ijd.13126"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13126","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,29]]},"assertion":[{"value":"2015-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}