{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:43:08Z","timestamp":1696408988857},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is a major public health concern worldwide. Given its rising prevalence, there is a pressing need to study its epidemiology. To date, no validated, cost\u2010effective, and patient self\u2010administered screening instrument exists that can reliably distinguish <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> from other skin conditions. Our aim is to develop an instrument that can validate a self\u2010reported <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> diagnosis quickly and with reasonable accuracy in a population at a distance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A one\u2010page, 13\u2010question atopic dermatitis screening and evaluation questionnaire (<jats:styled-content style=\"fixed-case\">ADSEQ<\/jats:styled-content>) was generated after literature review and consultation with dermatologists. The questionnaire was administered to 121 patients with and without <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in a dermatology clinic. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for all questions. The questions with the highest sensitivities were selected for logistic regression analysis, and a receiver operating characteristics curve was plotted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four scoring algorithms using different combinations of responses were then developed. A combination of Q7 (itching) and Qpic (the image questions combined) had the highest sensitivity (96.3%) and specificity (84%) for a diagnosis of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Cronbach's alpha coefficient was 0.71, indicating acceptable internal consistency. Other algorithms combining Qpic and questions about past diagnosis (Q1) or family history of atopy (Q5) also had sensitivities and specificities in the 80s or 90s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this pilot study, we found that our questionnaire was a valid and reliable self\u2010administered tool for distinguishing individuals with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> from individuals without <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13145","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T13:28:08Z","timestamp":1452864488000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pilot testing and validation of an atopic dermatitis screening and evaluation questionnaire"],"prefix":"10.1111","volume":"55","author":[{"given":"Chen A.","family":"Chen","sequence":"first","affiliation":[{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longde","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillary C.","family":"Tsibris","sequence":"additional","affiliation":[{"name":"Harvard Combined Dermatology Resident Program Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Warren Alpert Medical School Brown University Providence RI USA"},{"name":"Department of Epidemiology School of Public Health Brown University Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tricia Yunhui","family":"Li","sequence":"additional","affiliation":[{"name":"Channing Division of 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