{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:29:21Z","timestamp":1761823761770},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intralesional cryosurgery technology"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Incidences of basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) on the lower extremities in elderly patients are rising. Surgical approaches to the treatment of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> are subject to possible difficulties in healing, failure of skin grafts, and wound infection. This study assessed the efficacy of intralesional cryosurgery in the treatment of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> of the lower limbs in elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included eight patients aged &gt;60 years in whom a total of 10 nodular or superficial <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>s of the lower limbs were confirmed by biopsy. The patients' medical histories revealed comorbidities including hypertension, diabetes, hypercholesterolemia, venous insufficiency, and deep vein thrombosis of the legs, congestive heart failure, chronic renal failure, and ischemic heart disease. Using liquid nitrogen, an intralesional cryosurgery needle (CryoShape) was inserted into the tumor to facilitate its complete freezing. Treatment success was confirmed by biopsy taken approximately 3 months after complete healing of the cryo\u2010wound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average size of the lesions treated was 2.49 cm<jats:sup>2<\/jats:sup> (16.4 \u00d7 15.2 mm). Mean recovery time was 79.9 days. Biopsies were obtained at a mean of 85.3 days after the wound had healed. All 10 biopsies verified the complete destruction of the tumor. There was no evidence of wound infection or tumor recurrence over a follow\u2010up period of 28 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that a single intralesional cryosurgery session can completely eradicate <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> on the lower extremities in elderly patients. This technique is associated with relatively minor complications, is well tolerated, and represents a safe and effective therapeutic modality for <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> of the lower limbs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13168","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T17:55:07Z","timestamp":1452448507000},"page":"342-350","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Intralesional cryosurgery for the treatment of basal cell carcinoma of the lower extremities in elderly subjects: a feasibility study"],"prefix":"10.1111","volume":"55","author":[{"given":"Yaron","family":"Har\u2010Shai","sequence":"first","affiliation":[{"name":"Unit of Plastic Surgery Carmel Medical Center Haifa Israel"},{"name":"Bruce Rappaport Faculty of Medicine Israel Institute of Technology (Technion) Haifa 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