{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:19:06Z","timestamp":1783703946084,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association of vitiligo with the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> complex has been previously described in various populations worldwide. However, until now, no similar study has been conducted in Brazil. The aim of this study was to determine the association of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles with vitiligo in the population of southeast Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> samples from 116 patients with vitiligo and 243 healthy controls were obtained using the salting\u2010out technique. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I (A*, B*, C*) and class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1* and <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*) alleles were amplified by polymerase chain reaction with specific oligonucleotide sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The case\u2013control study identified susceptibility associations with alleles <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*02 (<jats:italic>P<\/jats:italic> = 0.0001, <jats:italic>Pc<\/jats:italic> = 0.0020, odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] = 2.68, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] = 1.69\u20134.26) and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*07 (<jats:italic>P<\/jats:italic> = 0.0001, <jats:italic>Pc<\/jats:italic> = 0.0013, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.66\u20134.34). The alleles <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*32 (<jats:italic>P<\/jats:italic> = 0.0156, <jats:italic>Pc<\/jats:italic> = 0.3120, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 22.43, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.12\u2013449.46) and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*06 (<jats:italic>P<\/jats:italic> = 0.0207, <jats:italic>Pc<\/jats:italic> = 0.1035, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 0.28, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 0.10\u20130.81) were associated with both localized and generalized vitiligo. The haplotype analysis revealed that A*02\u2010B*51\u2010C*15\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*07\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*02 (<jats:italic>P<\/jats:italic> = 0.0113), A*02\u2010B*15\u2010C*07\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*13\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*06 (<jats:italic>P<\/jats:italic> = 0.0340), and A*29\u2010B*44\u2010C*16\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*07\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*02 (<jats:italic>P<\/jats:italic> = 0.0340) were associated with a predisposition to the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results show that <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles and haplotypes may contribute to the pathogenesis of vitiligo in the Brazilian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13194","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T14:27:11Z","timestamp":1452868031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of class I and <scp>II HLA<\/scp> alleles and haplotypes with susceptibility to vitiligo: a study of patients with vitiligo from southeast Brazil"],"prefix":"10.1111","volume":"55","author":[{"given":"Leandro D.","family":"Ramire","sequence":"first","affiliation":[{"name":"Laboratory of Immunogenetics Lauro de Souza Lima Institute Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine V. C.","family":"Marcos","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics Lauro de Souza Lima Institute Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deise A. S.","family":"Godoy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lauro de Souza Lima Institute Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana C.","family":"de Souza\u2010Santana","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics Lauro de Souza Lima Institute Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399401003362"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_6_4_1","volume-title":"Vitiligo : A Comprehensive Monograph on Basic and Clinical Science","author":"Nordlund J","year":"2000"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00279.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23538.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.03.012"},{"key":"e_1_2_6_9_1","first-page":"12","article-title":"Oxidative stress in the blood of patients with active localized vitiligo","volume":"17","author":"Arican O","year":"2008","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00130.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.3.349"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962004000300010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1368-z"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/beha.2000.0097"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-6892.2004.00438.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(97)00024-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04288.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.06.004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.57719"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00141.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/archderm.1990.01670250062009","article-title":"Vitiligo is associated with HLA\u2010DR4 in black patients. 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