{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:33:20Z","timestamp":1770269600930,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JIPMER, Puducherry, India (Intramural Research Grant)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Recent studies have implicated the association between oxidative stress and inflammation in pathogenesis of psoriasis and its associated comorbidities. Hence, we undertook to study inflammatory markers such as sialic acids and the oxidative stress index (<jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content>) in patients with psoriasis vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty cases and 60 healthy controls were included in this cohort study. Disease severity was assessed by psoriasis area severity index scoring. Serum levels of oxidative stress (total oxidant status, total antioxidant status) and inflammation (highly sensitive C\u2010reactive protein [hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>], total sialic acid, protein bound sialic acid) markers were estimated in controls and cases at baseline and on follow\u2010up. <jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content> was calculated as the ratio of total oxidant status to total antioxidant status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline serum levels of <jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content>, hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, and sialic acids were significantly higher in cases compared to controls. Baseline <jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content> and sialic acids demonstrated a significant correlation with disease severity. After 12 weeks of therapy, there was a significant decline in <jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content> and serum levels of hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and sialic acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that oxidative stress and inflammation are significantly associated with psoriasis, and treatment with methotrexate results in a significant decline of both the inflammatory and oxidative stress parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13196","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T08:36:42Z","timestamp":1451378202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of antipsoriatic therapy on oxidative stress index and sialic acid levels in patients with psoriasis"],"prefix":"10.1111","volume":"55","author":[{"given":"Medha","family":"Rajappa","sequence":"first","affiliation":[{"name":"Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rathika","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malathi","family":"Munisamy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmisha","family":"Chandrashekar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalai Selvi","family":"Rajendiran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devinder Mohan","family":"Thappa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000062"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.09.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1684\/ejd.2011.1482","article-title":"Soluble biomarkers in psoriasis","volume":"21","author":"Enerback C","year":"2011","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(00)00358-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2012.02593.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.06.017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12451"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.02.004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03527.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0810384"},{"key":"e_1_2_8_15_1","first-page":"2445","article-title":"Increased levels of markers of oxidative stress and inflammation in patients with rheumatic mitral stenosis predispose to left atrial thrombus formation","volume":"7","author":"Pulimamidi VK","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00373-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00641.x"},{"key":"e_1_2_8_18_1","first-page":"221","article-title":"Oxidants and antioxidant status in psoriasis patients","volume":"21","author":"Pujari V","year":"2010","journal-title":"Biomed Res"},{"key":"e_1_2_8_19_1","first-page":"252","article-title":"Psoriasis: an oxidative stress condition","volume":"5","author":"Jyothi RS","year":"2011","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_20_1","first-page":"221","article-title":"Dyslipidemia and oxidative stress in patients of psoriasis","volume":"22","author":"Gupta M","year":"2011","journal-title":"Biomed Res"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-010-0043-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03410.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1553"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018171"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-013-0252-7"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1366-1"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20243"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.7.284"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr425"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:31:07Z","timestamp":1695573067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,29]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/ijd.13196"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13196","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,29]]},"assertion":[{"value":"2014-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}