{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:22:55Z","timestamp":1761513775444,"version":"3.40.3"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Altered levels of sex hormones have been observed in many autoimmune disorders, but there is no considerable data about pemphigus. The aim of this study is to compare serum total and free prolactin and dehydroepiandrosterone sulfate (<jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content>) levels between patients with pemphigus and healthy controls and to determine the correlation of these hormones with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 52 newly diagnosed cases of pemphigus and 57 healthy controls. Serum prolactin (total and free) and <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> were measured in all subjects. Data analyses were performed using <jats:styled-content style=\"fixed-case\">JMP<\/jats:styled-content>, Version 7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pemphigus patients had significantly higher levels of total and free serum prolactin (both <jats:italic>P<\/jats:italic> = 0.01) and lower levels of <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.005) than healthy controls. A significant association was found between severity of pemphigus and total prolactin levels (<jats:italic>r<\/jats:italic> = 0.40, <jats:italic>P<\/jats:italic> = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The patients with pemphigus had higher total and free prolactin and lower <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> concentrations, and patients with more severe disease had higher levels of serum total prolactin. These new data may suggest a potential role for sex hormones in the pathogenesis of pemphigus disease and provide new insights for the better management of this chronic and life\u2010threatening disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13199","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T04:02:56Z","timestamp":1456372976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus"],"prefix":"10.1111","volume":"55","author":[{"given":"Maryam","family":"Yousefi","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikoo","family":"Mozafari","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboobeh Sadat","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Baqiatallah University of Medical Science Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharareh","family":"Gholamin","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed\u2010Mostafa","family":"Razavi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Namazi","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Conjoint Faculty Member University of New South Wales Sydney NSW 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