{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:07:58Z","timestamp":1787616478005,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic hand and foot eczema (<jats:styled-content style=\"fixed-case\">CHFE<\/jats:styled-content>), a prevalent debilitating disorder affecting approximately 15% of the population, presents a socioeconomic and psychosocial burden for patients and often follows a chronic course, refractory to conventional therapies. Thus, a large need exists for more effective therapeutics; the excimer laser (308 nm) is effective for some inflammatory skin diseases, but its efficacy has not been evaluated for <jats:styled-content style=\"fixed-case\">CHFE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study is a retrospective chart review conducted on 30 patients with recalcitrant <jats:styled-content style=\"fixed-case\">CHFE<\/jats:styled-content> (19 with hand involvement, four with foot involvement, and seven with both) treated twice weekly with excimer laser (308 nm) single wavelength ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>)B radiation between January 2013 and December 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Improvements in clinical scores included a 69% reduction in average physician's global assessment (PGA) scores (from 2.77 at baseline to 0.87 after treatment, <jats:italic>P<\/jats:italic> &lt; 0.0001) with a parallel reduction in average modified total lesion\/symptom scores of 70% (from 10.2 to 3.1, <jats:italic>P<\/jats:italic> &lt; 0.0001). Only mild sunburn\u2010like reactions were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report evaluates excimer laser for patients with refractory <jats:styled-content style=\"fixed-case\">CHFE<\/jats:styled-content> and shows excellent and sustained efficacy for this treatment. Compared to other <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> therapies, excimer laser offers lower cumulative doses of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> radiation by targeting specific areas. This effective treatment should be considered alone or in combination with other established or newer therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13205","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T08:50:09Z","timestamp":1456476609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Use of 308 nm excimer laser for the treatment of chronic hand and foot eczema"],"prefix":"10.1111","volume":"55","author":[{"given":"Anjali","family":"Shroff","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Malajian","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology The Rockefeller University New York NY USA"},{"name":"College of Physicians and Surgeons Columbia University New York NY 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