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Their median age at initiation of lenalidomide was 62 years (range: 41\u201386 years). Subtypes of <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> included discoid lupus erythematosus (<jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content>) (<jats:italic>n<\/jats:italic> = 6), lupus panniculitis (<jats:italic>n<\/jats:italic> = 2), and subacute <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 1). Before the initiation of lenalidomide, all patients had been previously treated unsuccessfully or were intolerant to at least one antimalarial and one immunosuppressive agent. With lenalidomide, five patients achieved a complete response (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>), two a partial response, and two had no response (lupus panniculitis). Time to initial response (dose range: 2.5\u201310.0 mg\/d) varied from 2 weeks to 3 months; the median time to <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> in five patients was 3 months (range: 3\u20136 months). The median duration of lenalidomide therapy was 12 months (range: 2\u201367 months). The median duration of follow\u2010up was 48 months (range: 20\u2013103 months). Adverse effects included mild leukopenia; one patient had deep vein thrombosis of unclear etiology during a hospitalization. No patients developed or showed progression of systemic <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content> while receiving lenalidomide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lenalidomide was effective for the treatment of <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> (particularly <jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content>) but not for the treatment of lupus panniculitis in this series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13226","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T12:41:06Z","timestamp":1455367266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Lenalidomide treatment of cutaneous lupus erythematosus: the Mayo Clinic experience"],"prefix":"10.1111","volume":"55","author":[{"given":"Scott A.","family":"Kindle","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wetter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D. 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