{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:20:56Z","timestamp":1785280856668,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) is a chronic inflammatory disease that has been shown to be positively associated with dyslipidemia. However, the magnitude and types of the underlying lipid abnormalities have not been investigated. This study aims to conduct a systematic review and meta\u2010analysis to investigate the qualitative and quantitative association between <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> and dyslipidemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search of studies published from inception to April 1, 2015, was conducted using <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, Web of Science, and Cochrane library databases. Meta\u2010analyses of observational studies with both categorical and continuous outcome were performed. DerSimonian and Lard random effects models were utilized to calculate the pooled odds ratio and weighted mean difference (WMD). Publication bias was evaluated by funnel plot and Egger's test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies with 5242 subjects were included in this meta\u2010analysis. Patients with <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> were significantly more likely to have dyslipidemia, with a pooled odds ratio of 1.74 (95% confidence interval [CI]: 1.19\u20132.54, <jats:italic>P<\/jats:italic> = 0.004). <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> was associated with higher levels of triglycerides (WMD 83.37 mg\/dl, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.62\u2013166.12, <jats:italic>P<\/jats:italic> = 0.048), low\u2010density lipoprotein (18.75 mg\/dl, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u221217.21 to 54.72, <jats:italic>P<\/jats:italic> = 0.307), total cholesterol (19.22 mg\/dl, 95% CI \u22128.80 to 47.25, <jats:italic>P<\/jats:italic> = 0.179), and lower levels of high\u2010density lipoprotein cholesterol (\u22128.96 mg\/dl, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u221221.22 to 3.30, <jats:italic>P<\/jats:italic> = 0.152).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite considerable heterogeneity, this study demonstrated that <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> was significantly associated with an increased risk of dyslipidemia and higher triglyceride levels. For patients presenting with <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>, physicians should be cognizant of this association and consider screening them for dyslipidemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13234","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T12:35:48Z","timestamp":1455366948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Lichen planus and dyslipidemia: a systematic review and meta\u2010analysis of observational studies"],"prefix":"10.1111","volume":"55","author":[{"given":"Yi C.","family":"Lai","sequence":"first","affiliation":[{"name":"Rutgers New Jersey Medical School Newark NJ USA"},{"name":"Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yik W.","family":"Yew","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health Boston MA USA"},{"name":"National Skin Centre Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Preventive Medicine, and Pathology Rutgers New Jersey Medical School Newark NJ USA"},{"name":"Rutgers University School of Public Affairs and Administration Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.12.016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02458.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/742826"},{"key":"e_1_2_5_5_1","first-page":"53","article-title":"Diagnosis and treatment of lichen planus","volume":"84","author":"Usatine RP","year":"2011","journal-title":"Am Fam 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