{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:38:41Z","timestamp":1778715521344,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pyogenic granuloma (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) is a benign vascular tumor that can be treated by cautery (chemical or thermal), laser, excision, curettage, sclerotherapy, and cryotherapy. Topical timolol is emerging as a non\u2010invasive modality for the treatment of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited a series of 10 patients with <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>, who received treatment with 0.5% timolol maleate ophthalmic solution applied 4 times a day, 2 drops per dose. No other medication, topical or systemic, was given. Pulse rate, blood pressure, and blood glucose were monitored at baseline and weekly thereafter for the duration of treatment. <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> was done at baseline. The efficacy of the treatment was evaluated by considering a <jats:italic>complete response<\/jats:italic>, a <jats:italic>partial response,<\/jats:italic> and <jats:italic>no response<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 10 patients, four showed complete response within 3\u201324 days, with no recurrence at 3\u2010month follow\u2010up. Three patients each showed partial or no response. No local or systemic side effects were reported in any of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The response of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>s to <jats:italic>\u03b2<\/jats:italic> blockers seems to be variable. Although topical timolol has the advantage of minimal adverse events, ease of administration, and better cosmetic outcomes, it's efficacy in PG may not be universal unlike in infantile hemangiomas. Topical timolol may be a treatment option in young children, incapacitated elderly, and over delicate areas like face, nails, and gums where invasive modalities are not desirable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13237","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T12:40:45Z","timestamp":1455367245000},"page":"592-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Is timolol an effective treatment for pyogenic granuloma?"],"prefix":"10.1111","volume":"55","author":[{"given":"Divya","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Dermatology &amp; STD Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-105X","authenticated-orcid":false,"given":"Nidhi","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; STD Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devinder Mohan","family":"Thappa","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; STD Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"40","article-title":"Clinical inquiries. What's the best treatment for pyogenic granuloma?","volume":"59","author":"Gilmore A","year":"2010","journal-title":"J Fam Pract"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.41389"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630600823344"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12150"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13116"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12297"},{"key":"e_1_2_4_8_1","doi-asserted-by":"crossref","DOI":"10.5070\/D3203021726","article-title":"Resolution of recalcitrant pyogenic granuloma with laser, corticosteroid, and timolol therapy","volume":"20","author":"Millsop JW","year":"2014","journal-title":"Dermatol Online J"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12217"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01664.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922810391248"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09848.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.108"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(80)80392-6"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1991.tb00931.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01685.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12060"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13237","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:52:09Z","timestamp":1696405929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,12]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/ijd.13237"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13237","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,12]]},"assertion":[{"value":"2015-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}