{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:39:46Z","timestamp":1778823586333,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus of the lips (<jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content>) is not frequently described in the literature. The objective of this study is to investigate the clinical outline, behavior, and prognosis of <jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of patients with true oral lichen planus (LP) involving the lips, diagnosed and treated at our Oral Medicine Unit (University Federico <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> of Naples, Italy), have been collected and analyzed. Concurrently, a PubMed search was carried out from 1950 to March 2014 to assess epidemiological and clinical data about <jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our case series revealed 13 patients (female\/male ratio 0.4) with a mean (\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) age of 71.85\u00a0years (\u00b1\u00a06.72). The lower\/upper lip involvement ratio was 9, mainly with mixed clinical patterns (76.9%), generally including erosion and mild keratosis. In most cases, the lips were involved with other oral sites but displayed a better evolution of the lesions. The literature review showed 21 reports of <jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content> (35 patients, female\/male ratio 0.4) with a mean (\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) age of 45.35\u00a0years (\u00b1\u00a016.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the literature, erosive (28.57%) lower lip lesions showed a clear predominance (lower\/upper lip ratio 6.5). One case of malignant transformation was also reported. The prevalence of isolated <jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content> was clearly reported only in two studies, ranging from 0.51% to 8.9%. In our patients, lesions were mostly found at the inner border of the lower vermillion and presented a tendency for self\u2010limitation, or to regression after treatment, like cutaneous lesions. The lip lesions were small and easy to overlook, and therefore the prevalence of these lesions may have been underestimated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13265","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T08:24:20Z","timestamp":1458375860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Lichen planus of the lips: an intermediate disease between the skin and mucosa? Retrospective clinical study and review of the literature"],"prefix":"10.1111","volume":"55","author":[{"given":"Paolo","family":"Nuzzolo","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Celentano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences University Federico II of Naples Naples Italy"},{"name":"Melbourne Dental School The University of Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bucci","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Adamo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Ruoppo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Leuci","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele Davide","family":"Mignogna","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.49.89"},{"key":"e_1_2_5_6_1","first-page":"E310","article-title":"Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects","volume":"14","author":"Waal I","year":"2009","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.004"},{"key":"e_1_2_5_8_1","first-page":"305","article-title":"Superficial mycosis superimposing on isolated lichen planus of the lip: a case report and review of the literature","volume":"69","author":"Chiang CT","year":"2002","journal-title":"Cutis"},{"key":"e_1_2_5_9_1","first-page":"549","article-title":"Associated localization of morphea and lichen planus of the lip in a patient with vitiligo","volume":"49","author":"Melato M","year":"2000","journal-title":"Minerva Stomatol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1978.tb00958.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5070\/D31JM3N2GG","article-title":"Letter: Isolated annular lichen planus of lower lip","volume":"18","author":"Holmukhe S","year":"2012","journal-title":"Dermatol Online J"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.5070\/D34BT854WP"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546630903456367"},{"key":"e_1_2_5_14_1","first-page":"445","article-title":"Atypical case of oral lichen planus in a pediatric patient: clinical presentation and management","volume":"33","author":"Moraes PC","year":"2011","journal-title":"Pediatr Dent"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5070\/D338V355ZZ","article-title":"Oral lichen planus","volume":"14","author":"Johnson H","year":"2008","journal-title":"Dermatol Online J"},{"issue":"3","key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-4632.2007.03506.x","article-title":"Lichen planus with bullous manifestation on the lip.","volume":"46","author":"van Tuyll Serooskerken AM","year":"2007","journal-title":"Int J Dermatol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01338.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-005-0038-y"},{"key":"e_1_2_5_19_1","first-page":"210","article-title":"Isolated lichen planus of the lower lip","volume":"71","author":"Yu TC","year":"2003","journal-title":"Cutis"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00619.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1997.tb02788.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb03631.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb16963.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/014107689208500418","article-title":"Squamous cell carcinoma complicating lichen planus of the lip","volume":"85","author":"Harland CC","year":"1992","journal-title":"J R Soc Med"},{"issue":"276","key":"e_1_2_5_25_1","first-page":"283","article-title":"Imiquimod reactivation of lichen planus","volume":"89","author":"Domingues E","year":"2012","journal-title":"Cutis"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200702000321"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245964"},{"key":"e_1_2_5_28_1","first-page":"1402","article-title":"Case for diagnosis? Lichen planus of lip","volume":"32","author":"Whittle CH","year":"1939","journal-title":"Proc R Soc Med"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.113328"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00341.x"},{"key":"e_1_2_5_31_1","first-page":"154","article-title":"Oral lichen planus: a clinical study","volume":"20","author":"Bajaj DR","year":"2010","journal-title":"J Coll Phys Surg Pak"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120452"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0307-7772.2001.00516.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01142.x"},{"key":"e_1_2_5_35_1","first-page":"519","article-title":"Oral lichen planus: a review","volume":"58","author":"Carrozzo M","year":"2009","journal-title":"Minerva Stomatol"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/801974"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1429-3"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01781.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03029.x"},{"key":"e_1_2_5_40_1","first-page":"17","article-title":"Lichen planus: an update and review","volume":"90","author":"Sharma A","year":"2012","journal-title":"Cutis"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13265","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:32:05Z","timestamp":1695547925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,18]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/ijd.13265"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13265","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,18]]},"assertion":[{"value":"2015-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}