{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:14:22Z","timestamp":1695622462672},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Molluscum contagiosum (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) is a viral skin disease that presents with white, painless papules with central umbilication. In immunocompent individuals, <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> is usually a benign infection that resolves without intervention. In <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> positive people, symptoms of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> can be more severe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this systematic review is to analyze the literature on strategies for treating <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> in people concomitantly infected with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and subsequently make recommendations on best management strategies for these people.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Searches were conducted of the following electronic databases: <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, Cochrane Library, PubMed, <jats:styled-content style=\"fixed-case\">LILACS<\/jats:styled-content>, Ind<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>, Global Health, ClinicalTrials.Gov, and Current Controlled Trials. Grey literature was searched via the New York Academy of Medicine Grey Literature Report and Open Grey. References cited in previous reviews and references cited in studies identified as being possibly relevant were also reviewed. No language restrictions were imposed. Papers from 1980 to present were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results &amp; Discussion<\/jats:title><jats:p>Thirteen studies were included in this review. Two papers were comparative studies, one of which was randomized and neither of which were blinded. Ten papers were observational studies with heterogeneous populations. One study was a multicentre cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the poor quality of study design, wide array of outcome variables, and lack of objective evidence, no specific recommendation can be made for the treatment of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> in people infected with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>, other than the initiation of <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>. Despite the good impact <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> has made on prevalence of dermatologic disease, <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> remains an important cause of morbidity in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> positive populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13267","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:44:04Z","timestamp":1458373444000},"page":"956-966","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interventions for molluscum contagiosum in people infected with human immunodeficiency virus: a systematic review"],"prefix":"10.1111","volume":"55","author":[{"given":"Paul","family":"Martin","sequence":"first","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"CD004767","article-title":"Interventions for cutaneous molluscum contagiosum","author":"van der Wouden JC","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050554"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008186"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.10.1167"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203080-00004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0631"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680120095010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890460409"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5276.813"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.13.38"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540000400207"},{"key":"e_1_2_8_13_1","first-page":"144","article-title":"Skin diseases revealing human immunodeficiency virus infection in Mali. 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