{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:04:45Z","timestamp":1768482285945,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many inflammatory mediators and cytokines play important roles in the pathogenesis of acne vulgaris (<jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>). Information about the roles of these factors in the pathogenesis of the disease is limited. The purpose of this study was to evaluate levels of matrix metalloproteinase\u20101 (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101), <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102, and tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>) in <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> lesions. We selected 80 patients who presented at our dermatology department with <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>. Their lesions included papules, pustules, nodules, and comedones. Each specimen was evaluated by histopathology with hematoxylin and eosin staining, and subsequently by immunohistochemical analysis for <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102, and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> antibodies. A statistically significant difference between lesion groups emerged for <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 (<jats:italic>P<\/jats:italic> = 0.012) and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.029) scores. The <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 score was highest in nodules and lowest in comedones. The <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> score was also highest in nodules but lowest in papules. We conclude that different levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> expression can contribute to the development of different types of acne lesion and that the amount of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> released may contribute to lesion development. Further studies of novel treatment modalities might evaluate the different clinical types of <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ijd.13275","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T23:07:33Z","timestamp":1468624053000},"page":"1402-1407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A comparative study of <scp>MMP<\/scp>\u20101, <scp>MMP<\/scp>\u20102, and <scp>TNF<\/scp>\u2010<i>\u03b1<\/i> expression in different acne vulgaris lesions"],"prefix":"10.1111","volume":"55","author":[{"given":"Seyma","family":"Ozkanli","sequence":"first","affiliation":[{"name":"Department of Pathology Goztepe Training and Research Hospital Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse 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