{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:52:34Z","timestamp":1789149154627,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Lichen planus pigmentosus (\n                      <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>\n                      ) is a cosmetically distressing pigmentary disorder often posing a therapeutic challenge. Isotretinoin has been shown to be effective in oral and cutaneous\n                      <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>\n                      , but its role in\n                      <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>\n                      is yet unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy and safety of isotretinoin in the management of\n                      <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective study, 32 clinically and histologically proven patients with\n                      <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>\n                      were recruited. Subjects were treated with fixed low\u2010dose (20 mg\/day) oral isotretinoin once daily for 6 months along with topical sunscreens. Response was graded as mild (&lt;25%), moderate (26\u201350%), and good (&gt;50%) improvement based on decrease in intensity and progression of hyperpigmentation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010seven patients (17 females and 10 males), aged 20\u201362 years, completed the study. Twenty\u2010three (85.2%) patients had active disease and pruritus at presentation. Treatment outcome was moderate improvement in 15 patients (55.7%) followed by good in seven (21.8%) and mild in two (6.2%). Pruritus subsided at the earliest at 9\u201314 days, and disease stabilized by 4\u20136 weeks in treatment\u2010responsive patients. Patients with a shorter duration (\u22645 years) of disease and limited body area involvement had a better outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Low\u2010dose isotretinoin seems to be a promising treatment modality in stabilizing and decreasing the pigmentation in\n                      <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>\n                      particularly in early and limited disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.13293","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T13:48:07Z","timestamp":1460296087000},"page":"1048-1054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Low\u2010dose oral isotretinoin therapy in lichen planus pigmentosus: an open\u2010label non\u2010randomized prospective pilot study"],"prefix":"10.1111","volume":"55","author":[{"given":"Sendhil Kumaran","family":"Muthu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma N.","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Pathology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrinder Jit","family":"Kanwar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder","family":"Parsad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.02880.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.1.152"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03460.x"},{"key":"e_1_2_6_5_1","first-page":"282","article-title":"Pigmented and reticulated plaques of folds. 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