{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:14:25Z","timestamp":1789186465431,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Abstract<\/jats:title>Growth differentiation factor\u201015 (GDF<\/jats:styled-content>\u201015), a member of the transforming growth factor\u2010\u03b2<\/jats:italic> superfamily of cytokines, plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate serum GDF<\/jats:styled-content>\u201015 levels and their relationships with disease\u2010related variables in patients with Beh\u00e7et's disease (BD<\/jats:styled-content>). Forty\u2010six patients diagnosed with BD<\/jats:styled-content> and 30 demographically matched healthy control subjects participated in the study. GDF<\/jats:styled-content>\u201015 levels were measured in blood samples from patients and controls. The Beh\u00e7et's Disease Current Activity Form (BDCAF<\/jats:styled-content>) was used to evaluate the disease activity of BD<\/jats:styled-content>. There were no significant differences between the two groups in C\u2010reactive protein (CRP<\/jats:styled-content>) level, mean erythrocyte sedimentation rate (ESR<\/jats:styled-content>), age, body mass index, and mean GDF<\/jats:styled-content>\u201015 levels (P<\/jats:italic> > 0.05). Serum GDF<\/jats:styled-content>\u201015 levels were positively correlated with findings for peripheral arthritis and CRP<\/jats:styled-content>, and with BDCAF<\/jats:styled-content> erythema nodosum, BDCAF<\/jats:styled-content> arthralgia, and BDCAF<\/jats:styled-content> arthritis scores. Patients with BD<\/jats:styled-content> were divided into two groups according to the presence of peripheral arthritis; nine subjects (20%) were positive for peripheral arthritis. Serum ESR<\/jats:styled-content>, CRP<\/jats:styled-content>, white blood cell counts, and GDF<\/jats:styled-content>\u201015 levels were significantly higher in the group that was positive for peripheral arthritis (P<\/jats:italic> < 0.05). GDF<\/jats:styled-content>\u201015 may play a role in the progression and pathway of Beh\u00e7et's joint involvement and erythema nodosum that is independent of classic inflammatory response measures.<\/jats:p>","DOI":"10.1111\/ijd.13309","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T22:38:31Z","timestamp":1464043111000},"page":"1289-1294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serum GDF<\/scp>\u201015 level in Beh\u00e7et's disease: relationships between disease activity and clinical parameters"],"prefix":"10.1111","volume":"55","author":[{"given":"Mustafa Akif","family":"Sar\u0131y\u0131ld\u0131z","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Dicle University Diyarbak\u0131r 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