{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:06:50Z","timestamp":1773680810509,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Febrile ulceronecrotic Mucha\u2010Habermann disease (<jats:styled-content style=\"fixed-case\">FUMHD<\/jats:styled-content>) is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta (<jats:styled-content style=\"fixed-case\">PLEVA<\/jats:styled-content>) characterized by a rapidly progressive course with predominant ulceronecrotic lesions associated with fever and systemic manifestations. First described by Degos in 1966, it carries a high morbidity and is potentially fatal. The exact pathogenesis is not clear, but it is proposed to be the result of hypersensitivity reaction to an infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here we report the case of an 8\u2010year\u2010old boy with <jats:styled-content style=\"fixed-case\">FUMHD<\/jats:styled-content> in the eastern province of Saudi Arabia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient presented with pyrexia, fatigue, arthralgia, and worsening of his already existing skin lesions of <jats:styled-content style=\"fixed-case\">PLEVA<\/jats:styled-content>. There was an extensive painful erythematous maculopapular rash, some lesions ulcerated and necrotic, involving the face, trunk, limbs, and flexures. A diagnosis of <jats:styled-content style=\"fixed-case\">FUMHD<\/jats:styled-content> was made based on clinical and histological features. The skin lesions responded extremely well to oral methotrexate, with almost complete healing after 4 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe a rare variant of <jats:styled-content style=\"fixed-case\">PLEVA<\/jats:styled-content>, namely <jats:styled-content style=\"fixed-case\">FUMHD<\/jats:styled-content>, in an 8\u2010year\u2010old boy who showed a remarkably favorable response to methotrexate, as manifested by near total clearance of the skin lesions without scarring or hyperpigmentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13323","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T03:16:58Z","timestamp":1467429418000},"page":"1205-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Febrile ulceronecrotic Mucha\u2013Habermann disease in an 8\u2010year\u2010old boy responding to methotrexate"],"prefix":"10.1111","volume":"55","author":[{"given":"Jehad","family":"Alratrout","sequence":"first","affiliation":[{"name":"Department of Dermatology Qatif Central Hospital Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Alshammasi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Qatif Central Hospital Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naseem","family":"Ansari","sequence":"additional","affiliation":[{"name":"ExpressMed Laboratories Kingdom of Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.023"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01531.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708010-00004"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.058"},{"key":"e_1_2_3_6_1","first-page":"481","article-title":"Le parapsoriasis ulceronecrotique hyperthermique","volume":"93","author":"Degos R","year":"1966","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.06.009"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-015-0726-5"},{"key":"e_1_2_3_9_1","first-page":"123","article-title":"Mucha\u2010Habermann disease and its febrile ulceronecrotic 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