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We researched carotid extra\u2010medial thickness (<jats:styled-content style=\"fixed-case\">cEMT<\/jats:styled-content>), a novel ultrasound parameter for atherosclerotic vessel wall changes, and carotid intima media thickness (<jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>), a widely accepted marker of subclinical atherosclerosis, in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, and we evaluated the relationship between these two parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In total, 31 patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> were matched to 26 control subjects based on age, gender, and major cardiovascular risk factors. Laboratory parameters, including lipid profile, were measured for both patients and controls. B\u2010mode ultrasonography was used to assess the <jats:styled-content style=\"fixed-case\">cEMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in the <jats:styled-content style=\"fixed-case\">cEMT<\/jats:styled-content> values between the patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and the control group (<jats:italic>P<\/jats:italic> = 0.90). <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> group was significantly higher compared with the control group (<jats:italic>P<\/jats:italic> = 0.021). There was a significant positive correlation between <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">cEMT<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = 0.585, <jats:italic>P<\/jats:italic> = 0.001). Both <jats:styled-content style=\"fixed-case\">cEMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> were positively correlated with age and the presence of arthritis. There was linear correlation with sedimentation, C\u2010reactive protein, and <jats:styled-content style=\"fixed-case\">cEMT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To the best of our knowledge, this is the first study to evaluate both <jats:styled-content style=\"fixed-case\">cEMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. This study presents morphological evidence of subclinical atherosclerosis in terms of <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>. Although there was no significant increment in <jats:styled-content style=\"fixed-case\">cEMT<\/jats:styled-content>, it has the potential to assess endothelial dysfunction in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. Further studies are required to confirm this finding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13324","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T07:17:22Z","timestamp":1464333442000},"page":"1124-1130","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extra\u2010medial thickness of carotid artery in patients with Beh\u00e7et's disease: evaluation of atherosclerotic vessel wall changes with a novel carotid artery ultrasound index"],"prefix":"10.1111","volume":"55","author":[{"given":"Betul","family":"Sereflican","sequence":"first","affiliation":[{"name":"Departments of Dermatology Medical Faculty Abant Izzet Baysal University Bolu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul","family":"Kizildag","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical Faculty Abant Izzet Baysal University Bolu 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