{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:28:54Z","timestamp":1789565334106,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Primary cutaneous CD<\/jats:styled-content>4+<\/jats:sup> small\u2013medium pleomorphic T cell lymphoma (SMPTCL<\/jats:styled-content>) is a low\u2010grade cutaneous T cell lymphoma. Its clinical and histopathologic features are comparable with those of CD<\/jats:styled-content>8+<\/jats:sup> lymphoid proliferations (LP<\/jats:styled-content>s) of the ear and acral sites.<\/jats:p><\/jats:sec>Objectives<\/jats:title>We performed a retrospective analysis of patients with CD<\/jats:styled-content>4+<\/jats:sup> SMPTCL<\/jats:styled-content> or CD<\/jats:styled-content>8+<\/jats:sup> LP<\/jats:styled-content> to elucidate the clinical course, prognosis, and outcomes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Demographic, clinical, and treatment data were reviewed. Histopathologic data based on architectural, cytomorphologic, and immunohistochemical features were assessed. Immunohistochemical staining for T and B cell markers was evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 25 patients including 22 with CD<\/jats:styled-content>4+<\/jats:sup> SMPTCL<\/jats:styled-content> and three with CD<\/jats:styled-content>8+<\/jats:sup> LP<\/jats:styled-content> were identified. All patients presented with a single lesion, predominantly on the head, neck, or upper trunk (84%). No patients showed extracutaneous disease at any evaluation. The most common histopathologic changes showed a dense nodular infiltrate of small cells with hyperchromatic nuclei without significant follicular or adnexal involvement. Patients were treated with excision (48%), local radiation (28%), or topical or intralesional steroids (24%). All patients achieved complete resolution of disease. Five patients demonstrated cutaneous relapse at new sites.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The CD<\/jats:styled-content>4+<\/jats:sup> SMPTCL<\/jats:styled-content>\/CD<\/jats:styled-content>8+<\/jats:sup> LP<\/jats:styled-content> subgroup usually presents with solitary lesions and demonstrates an indolent clinical course. Typical presentation, classic histopathology, widespread expression of follicular T helper cell markers, and loss of a T cell antigen are diagnostic features of CD<\/jats:styled-content>4+<\/jats:sup> SMPTCL<\/jats:styled-content>, whereas monomorphous CD<\/jats:styled-content>8+<\/jats:sup> infiltrate without follicular T helper cell markers is consistent with CD<\/jats:styled-content>8+<\/jats:sup> LP<\/jats:styled-content>. Local skin\u2010directed therapy is appropriate in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13340","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T03:16:58Z","timestamp":1467429418000},"page":"1248-1254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Long\u2010term follow\u2010up and management of small and medium\u2010sized CD<\/scp>4+<\/sup> T cell lymphoma and CD<\/scp>8+<\/sup> lymphoid proliferations of acral sites: a multicenter experience"],"prefix":"10.1111","volume":"55","author":[{"given":"Pooja","family":"Virmani","sequence":"first","affiliation":[{"name":"Dermatology Service Memorial Sloan\u2013Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Jawed","sequence":"additional","affiliation":[{"name":"Dermatology Service Memorial Sloan\u2013Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L.","family":"Myskowski","sequence":"additional","affiliation":[{"name":"Dermatology Service Memorial Sloan\u2013Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Lymphoma Service Department of Medicine Memorial Sloan\u2013Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Skripnik Lucas","sequence":"additional","affiliation":[{"name":"Dermatology Service Memorial Sloan\u2013Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Moskowitz","sequence":"additional","affiliation":[{"name":"Lymphoma Service Department of Medicine Memorial Sloan\u2013Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Pulitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2013Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Zain","sequence":"additional","affiliation":[{"name":"Departments of Hematology and Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Departments of Hematology and Hematopoietic Cell 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