{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:32Z","timestamp":1792043132563,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Istanbul Medeniyet University Scientific Research Project 2013","award":["TTU-2013-431"],"award-info":[{"award-number":["TTU-2013-431"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxidative stress may play an important role in the pathogenesis of psoriasis. Glutathione <jats:italic>S<\/jats:italic>\u2010transferases (<jats:styled-content style=\"fixed-case\">GST<\/jats:styled-content>s) make up a group of antioxidant enzymes. Cytochrome p450 (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>) enzymes can influence oxidation and reduction reactions. We investigated the potential effects of <jats:styled-content style=\"fixed-case\">GST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content> enzymes in the pathogenesis of psoriasis. The study included 32 psoriasis patients and 22 healthy subjects. Psoriasis patients were administered 20 sessions of narrowband ultraviolet B phototherapy. Expressions of <jats:styled-content style=\"fixed-case\">GST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content> enzymes were assessed by immunohistochemical staining. Expression levels of <jats:styled-content style=\"fixed-case\">GSTK<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">GSTM<\/jats:styled-content>1, and <jats:styled-content style=\"fixed-case\">GSTT<\/jats:styled-content>1 were significantly higher in psoriasis than in control tissues (<jats:italic>P<\/jats:italic> = 0.022, <jats:italic>P<\/jats:italic> = 0.001, and <jats:italic>P<\/jats:italic> = 0.006, respectively). Pre\u2010 and post\u2010treatment expression was similar. Expression of <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>1A1 and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2E1 was significantly higher in pre\u2010 (<jats:italic>P<\/jats:italic> = 0.003 and <jats:italic>P<\/jats:italic> = 0.001, respectively) and post\u2010treatment (<jats:italic>P<\/jats:italic> = 0.003 and <jats:italic>P<\/jats:italic> = 0.001, respectively) psoriatic tissues than in control tissues. No significant differences in <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>1B1 levels between the study and control groups were detected before treatment (<jats:italic>P<\/jats:italic> &gt; 0.05). However, <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>1B1 levels were higher in post\u2010treatment psoriatic tissue than in control tissue (<jats:italic>P<\/jats:italic> = 0.045). The significant increases in expression of <jats:styled-content style=\"fixed-case\">GSTK<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">GSTM<\/jats:styled-content>1, and <jats:styled-content style=\"fixed-case\">GSTT<\/jats:styled-content>1 in psoriasis may reflect the increased activation of <jats:styled-content style=\"fixed-case\">GST<\/jats:styled-content> in response to excessive free radical formation from activated neutrophils or ultraviolet exposure to maintain antioxidant capacity in psoriasis. Furthermore, expressions of <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>1A1 and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2E1 represent important enzymatic systems in psoriasis. These findings suggest that psoriasis is an oxidative stress condition, although phototherapy does not affect these enzymatic systems. Further investigation is required.<\/jats:p>","DOI":"10.1111\/ijd.13343","type":"journal-article","created":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T01:21:37Z","timestamp":1473470497000},"page":"225-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["An investigation of cytochrome p450 (<scp>CYP<\/scp>) and glutathione <i>S<\/i>\u2010transferase (<scp>GST<\/scp>) isoenzyme protein expression and related interactions with phototherapy in patients with psoriasis vulgaris"],"prefix":"10.1111","volume":"56","author":[{"given":"Ayse S.","family":"Karadag","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba K.","family":"Uzun\u00e7akmak","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyma","family":"Ozkanli","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil","family":"Oguztuzun","sequence":"additional","affiliation":[{"name":"Department of Biology School of Medicine K\u0131r\u0131kkale University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busra","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Biology Scientific Technical Research and Application Center Hitit University \u00c7orum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Akbulak","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Istanbul Medeniyet University Istanbul 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