{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:44:08Z","timestamp":1784735048119,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"KLOX Technologies Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although a variety of laser\/light\u2010based devices have been reported to be effective for the treatment of acne, long\u2010term data on efficacy and safety in the management of moderate and severe inflammatory acne is lacking. The objective of this 12\u2010week clinical trial was to evaluate the efficacy and safety of the <jats:styled-content style=\"fixed-case\">KLOX<\/jats:styled-content> BioPhotonic System, a <jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content> blue light device using specific photo\u2010converter chromophores, in the treatment of moderate to severe acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One patient hemiface was randomly selected to receive 6 weeks of treatment (twice weekly) with the <jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content> light and the photo\u2010converter chromophores whereas the contralateral hemiface was not treated with the BioPhotonic System. All patients were provided with a skin cleanser and a non\u2010comedogenic cream with ultraviolet protection to be used on the entire face during the treatment period. Following completion of the 6\u2010week treatment period, the patient was followed for an additional 6 weeks. Efficacy was assessed through changes in acne severity using the Investigator's Global Assessment (<jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content>) scale and inflammatory acne lesion counts, both evaluated against baseline at weeks 6 and 12. Safety was assessed through physical exam, vital signs, laboratory evaluations, and physician and patient reporting of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A reduction of at least two grades in <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> scale severity was demonstrated in 51.7% of patients at week 12. Furthermore, at week 12, subjects with a baseline <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> grade of 3 (moderate) demonstrated a success rate (2 or greater grade drop) of 45.3% whereas patients with a baseline <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> grade of 4 (severe) demonstrated a success rate of 61.1%. Acne inflammatory lesion counts confirmed these results, with a reduction of at least 40% of lesions in 81.6% of treated hemifaces after 12 weeks. Treatment was considered as safe and well tolerated, with no serious adverse event and no patient discontinuation from the study from any adverse event. Patients' quality of life was also improved with a decrease of pain linked to acne after the 6\u2010week treatment period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The BioPhotonic System comprised of <jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content> blue\u2010light phototherapy and photo\u2010converter chromophores was found to be efficacious and safe, with a sustained clinical response at 12 weeks for the management of moderate to severe facial inflammatory acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13349","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T23:36:38Z","timestamp":1472600198000},"page":"1321-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["A multicenter, randomized, split\u2010face clinical trial evaluating the efficacy and safety of chromophore gel\u2010assisted blue light phototherapy for the treatment of acne"],"prefix":"10.1111","volume":"55","author":[{"given":"Christina","family":"Antoniou","sequence":"first","affiliation":[{"name":"1st Department of Dermatology University of Athens Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clio","family":"Dessinioti","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology University of Athens Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Sotiriadis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aristotle University of Thessaloniki Medical School Papageorgiou General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kalokasidis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aristotle University of Thessaloniki Medical School Papageorgiou General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kontochristopoulos","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Petridis","sequence":"additional","affiliation":[{"name":"3rd Department of Dermatology Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Rigopoulos","sequence":"additional","affiliation":[{"name":"University of Athens Attikon University General Hospital of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Vezina","sequence":"additional","affiliation":[{"name":"KLOX Technologies Inc. Laval Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Nikolis","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery University of Montreal Montreal Canada"},{"name":"Victoria Park Research Centre Plastic Surgery Section Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13462"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00175.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09047.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.056"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04374.x"},{"key":"e_1_2_6_9_1","unstructured":"DessiniotiC KatsambasA MasouriS et al.Short\u2010contact low\u2010dose methyl aminolaevulinate\u2010photodynamic therapy (MAL\u2010PDT) for the treatment of acne vulgaris: a hospital\u2010based case series. 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