{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:54:09Z","timestamp":1769158449032,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is an autoimmune depigmentation disorder. Polymorphisms in the vitamin D receptor (<jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>) have been found to be associated with vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the potential association between <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content> gene polymorphisms (<jats:italic>Apa<\/jats:italic>I, <jats:italic>Taq<\/jats:italic>I, and <jats:italic>Fok<\/jats:italic>I) and vitiligo susceptibility, and to detect if there is correlation between serum 25\u2010hydroxyvitamin D [25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D] levels and vitiligo and between <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content> gene polymorphisms and 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D levels in vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Seventy\u2010five patients with vitiligo and 75 age and sex\u2010matched controls were subjected to detailed history taking and dermatological examination to determine the extent and clinical type of vitiligo. A blood sample (5 ml) was retrieved to investigate <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content> gene polymorphisms and serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that the serum level of vitamin D is statistically significantly lower in patients than controls. The frequency of the <jats:italic>Apa<\/jats:italic>I variant a allele, the variant genotype (aa), and the variant genotype (tt) were significantly higher among the vitiligo cases than among controls. Our study also showed that the serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D levels were not significantly different among the different <jats:italic>Apa<\/jats:italic>I, <jats:italic>Taq<\/jats:italic>I, and <jats:italic>Fok<\/jats:italic>I genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study showed that serum level of 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D is statistically significantly lower in patients than controls, so screening for vitamin D deficiency seems of value in patients with vitiligo for the possibility of vitamin D supplementation. We also report that <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content> gene polymorphisms may be a risk for the development of vitiligo in an Egyptian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13363","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T23:04:36Z","timestamp":1468623876000},"page":"1329-1335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of the correlation between serum levels of vitamin D and vitamin D receptor gene polymorphisms in an Egyptian population"],"prefix":"10.1111","volume":"55","author":[{"given":"Shereen","family":"Sobeih","sequence":"first","affiliation":[{"name":"Dermatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba M.","family":"Mashaly","sequence":"additional","affiliation":[{"name":"Dermatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba","family":"Gawdat","sequence":"additional","affiliation":[{"name":"Dermatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalda","family":"Amr","sequence":"additional","affiliation":[{"name":"Molecular Genetics National Research Centre Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Fawzy Abdel","family":"Hamid","sequence":"additional","affiliation":[{"name":"Dermatology National Research Centre Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Shaalan","sequence":"additional","affiliation":[{"name":"Dermatology National Research Centre Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00023.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2004.00825.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987100"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0093"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2005.04.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.07.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1518"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.6030"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2005.00167.x"},{"key":"e_1_2_7_14_1","first-page":"1291","article-title":"Al Eisa A, Huma R, Mulekar S. 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