{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:38:27Z","timestamp":1757309907232},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Actinic cheilitis is a potentially malignant condition caused mainly by chronic sun exposure. Here we aim to evaluate the role of hypoxia, angiogenesis, and lymphatic density in the clinical and morphological progression of a series of cases of actinic cheilitis.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>Immunohistochemistry was used to evaluate positivity to hypoxia\u2010inducible factor (HIF<\/jats:styled-content>)\u20101\u03b1<\/jats:italic>, vascular endothelial growth factor (VEGF<\/jats:styled-content>)\u2010C, and D2\u201340 in 40 cases of actinic cheilitis of the lower lip.<\/jats:p><\/jats:sec>Results<\/jats:title>The cases studied exhibited variable degrees of positivity to the markers. The median number of lymphatic vessels was 3.2, 2.4, and 3.0 in lesions showing no epithelial dysplasia (NED<\/jats:styled-content>) and with mild (MED<\/jats:styled-content>) and moderate (MOED<\/jats:styled-content>) epithelial dysplasia, respectively. The median VEGF<\/jats:styled-content>\u2010C positivity index was 82.44% (NED<\/jats:styled-content>), 92.74% (MED<\/jats:styled-content>), and 82.83% (MOED<\/jats:styled-content>), and the median HIF<\/jats:styled-content>\u20101\u03b1<\/jats:italic> positivity index was 11.57% (NED<\/jats:styled-content>), 5.26% (MED<\/jats:styled-content>), and 13.55% (MOED<\/jats:styled-content>). No significant differences in lymphatic density or median VEGF<\/jats:styled-content>\u2010C and HIF<\/jats:styled-content>\u20101\u03b1<\/jats:italic> positivity indices were observed between histological grades or clinical presentations of actinic cheilitis (P<\/jats:italic> > 0.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Although representing early events in lip carcinogenesis, the present results suggest that hypoxia, angiogenesis, and lymphangiogenesis do not influence the morphological or clinical progression of actinic cheilitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13365","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T23:03:52Z","timestamp":1468623832000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis"],"prefix":"10.1111","volume":"55","author":[{"given":"Nat\u00e1lia G.","family":"Barbosa","sequence":"first","affiliation":[{"name":"Oral Pathology Post\u2010Graduate Program Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9lia B.","family":"Souza","sequence":"additional","affiliation":[{"name":"Oral Pathology Post\u2010Graduate Program Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassiano F. W.","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Department of Dentistry State University of Paraiba Campina Grande Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ericka J. D.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Oral Pathology Post\u2010Graduate Program Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00606.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.09.040"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00335.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R200030200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9055-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-7754(01)90021-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.030008449.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.06.020"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0886-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000028824.03032.AB"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0915-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603518"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.4072"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2266-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-011-0261-7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000100013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.09.016"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01680.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00571.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.04.007"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.09.017"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2011.12.038"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(11)60008-9"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.11.018"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.92968"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324926"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21388"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13365","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:39:17Z","timestamp":1696365557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,5]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/ijd.13365"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13365","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,5]]},"assertion":[{"value":"2015-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}