{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:25:14Z","timestamp":1779114314195,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>) and Stevens\u2013Johnson syndrome (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>) are severe mucocutaneous reactions that incur high mortality, and in which the systemic application of corticosteroids remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to determine the optimal protocols for the use of corticosteroids and treatment measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of 70 patients with <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> who were hospitalized between January 2008 and May 2015 in the Department of Dermatology, Shandong Provincial Hospital, and treated with corticosteroids. Expected and actual mortality rates in patients treated with different doses of corticosteroids, according to <jats:styled-content style=\"fixed-case\">SCORTEN<\/jats:styled-content>, were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diagnoses associated with initial corticosteroid use differed significantly between the low\u2010 and high\u2010dose groups (<jats:italic>P<\/jats:italic> = 0.041). There were significant differences between expected and actual mortality rates according to the use of corticosteroid therapy (<jats:italic>P<\/jats:italic> = 0.0168, standardized mortality ratio [<jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>] = 0.30). There was a statistical difference between expected and actual mortality rates in the low\u2010dose group (<jats:italic>P<\/jats:italic> = 0.0145, <jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content> = 0.20). Serum albumin levels were significantly lower in patients administered corticosteroids additive therapy (31.12 \u00b1 8.32 g\/l vs. 35.54 \u00b1 5.82 g\/l; <jats:italic>P<\/jats:italic> = 0.016), and the rate of use of antibiotics was higher among patients in the additive therapy group than in the non\u2010additive group (94.7% vs. 60.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our research supports the use of corticosteroids for the systemic treatment of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>. Corticosteroids should be used in a timely manner and in accordance with disease severity, age, underlying diseases, serum albumin level, and concurrent treatment with antimicrobial therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13379","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T09:59:29Z","timestamp":1474538369000},"page":"1408-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A retrospective analysis of Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis treated with corticosteroids"],"prefix":"10.1111","volume":"55","author":[{"given":"Wenmin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology Shandong Provincial Hospital Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of 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