{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:56:54Z","timestamp":1770487014879,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) is a severe, chronic, and potentially life\u2010threatening autoimmune blistering disease that affects the skin and mucous membranes. Rituximab is a monoclonal anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 antibody which has been used increasingly in the therapy of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study sought to test the efficacy and safety of rituximab as an adjuvant therapy by retrospective analysis of clinical and immunological data for 29 patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> who were treated with rituximab between 2010 and 2015. Response to therapy, duration of clinical remission, serology of the response, and adverse effects of rituximab were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean \u00b1 standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) follow\u2010up time was 17.48 \u00b1 13.18 months. In all patients, findings showed either a decrease in antibody titers or that antibodies were completely undetectable after therapy. Rituximab use resulted in a significant reduction in steroid dosage during follow\u2010up. At the end of the follow\u2010up period, 26 patients (96.2%) had achieved complete remission with or without therapy (one patient had no follow\u2010up and one patient had died, most probably as the result of a thromboembolic event). In 44.4% of patients, a clinical relapse occurred after a mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> period of 13.1 \u00b1 4.7 months after the initiation of rituximab therapy. Relapses were managed with additional infusions of rituximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rituximab is a beneficial and relatively safe adjuvant treatment for <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> that facilitates prolonged clinical remission and has a significant steroid\u2010sparing effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13400","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T09:57:56Z","timestamp":1474538276000},"page":"1362-1368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy and safety of rituximab therapy in patients with pemphigus vulgaris: first report from Turkey"],"prefix":"10.1111","volume":"55","author":[{"given":"Soner","family":"Uzun","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Akdeniz University Antalya 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