{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:38:51Z","timestamp":1770565131302,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>As numbers of transplant recipients and survival rates increase, the vulnerability of this population to several malignancies also rises. Non\u2010melanoma skin cancer (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>) carries the highest rates of morbidity and mortality in this population. To avoid these malignancies, it is necessary to identify particular risk factors in transplant recipients and to follow preventive protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> databases were reviewed using as keywords the medical subject headings (Me<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>) \u201ctransplantation\u201d, \u201cskin neoplasm\u201d and \u201cprevention\u201d. The search was limited to clinical trials, randomized clinical trials and case\u2013control studies conducted during the previous 20 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most important risk factors for the development of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>s in the transplant recipient population are cumulative ultraviolet radiation exposure, use of immunosuppressive agents (especially azathioprine as a photosensitizing agent) and infections by human papillomaviruses. The use of sun protection and retinoids were identified as possible protective factors. Other potential therapies, such as antioxidants, difluormethylornithine and cyclooxygenase\u20102 inhibitors, require further study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient risk factors for the development of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> should be reviewed during the transplant consultation. Individuals found to be at increased risk should undergo closer follow\u2010up and preventive care counseling. This article proposes an algorithm for the prevention of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13409","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T06:46:53Z","timestamp":1479710813000},"page":"370-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Basic aspects of the pathogenesis and prevention of non\u2010melanoma skin cancer in solid organ transplant recipients: a review"],"prefix":"10.1111","volume":"56","author":[{"given":"H\u00e9ctor C.","family":"Perez","sequence":"first","affiliation":[{"name":"Organ and Tissue Transplant Group Department of Surgery Faculty of Medicine Universidad Nacional de Colombia Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiomara","family":"Benavides","sequence":"additional","affiliation":[{"name":"Organ and Tissue 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