{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:14:46Z","timestamp":1790111686177,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In patients with vitiligo, the clinical and laboratory features of the disease may vary according to time of onset. This is addressed in the literature by only a few studies with conflicting results. The aim of this study was to determine the demographic and clinical features of patients with non\u2010segmental vitiligo and to establish the association between vitiligo and autoimmune diseases with a focus on time of disease onset. A total of 224 vitiligo patients for whom complete medical records were available were evaluated retrospectively. Demographic data, scores on the Vitiligo Area Score Index (<jats:styled-content style=\"fixed-case\">VASI<\/jats:styled-content>), clinical features, vitiligo disease activity, repigmentation status, presence of any accompanying autoimmune disease, antinuclear antibody (<jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>) titers, serum levels of glucose, thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>), thyroxine (T4) hormone, anti\u2010thyroid peroxidase (anti\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>), and anti\u2010thyroglobulin (anti\u2010<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>) were recorded. The prevalence of halo nevi was significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.001) among children than in other patient groups. The prevalence of leukotrichia was higher in adults with adult\u2010onset disease than in either pediatric patients or adults with childhood\u2010onset disease (<jats:italic>P<\/jats:italic> = 0.002). Both anti\u2010<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> and anti\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> levels were significantly higher in adults with adult\u2010onset disease than in pediatric patients and adult patients with childhood\u2010onset disease. The prevalence of autoimmune disease was 22.2%. Anti\u2010<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> levels were significantly higher in patients with treatment\u2010related repigmentation than in those without repigmentation. This study shows that clinical features and associations with autoimmune disease may vary according to the age of onset of vitiligo.<\/jats:p>","DOI":"10.1111\/ijd.13425","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T04:27:16Z","timestamp":1483590436000},"page":"341-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of age of onset on disease characteristics in non\u2010segmental vitiligo"],"prefix":"10.1111","volume":"56","author":[{"given":"Berna","family":"Solak","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar Sevimli","family":"Dikicier","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sakarya University Training and Research Hospital Sakarya 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