{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:50:00Z","timestamp":1782928200686,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hidradenitis suppurativa (\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      ) is a chronic inflammatory skin disorder of the follicular epithelium.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The objective of the present study was to evaluate the effectiveness of the combination of tetracycline with colchicine in the treatment of\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty patients (10 women and 10 men) with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      were included in an open, prospective, pilot study. All patients were treated with 100 mg minocycline administered orally once per day in combination with 0.5 mg colchicine administered twice per day for 6 months followed by a maintenance regimen of 0.5 mg colchicine administered orally twice per day for 3 months. Patients were examined at baseline and thereafter every 3 months for a total of 9 months. The efficacy of the treatment was evaluated using a physician's global assessment (\n                      <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>\n                      ) scale, the Hurley scoring system, and the Dermatology Life Quality Index (\n                      <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant improvement in clinical manifestation was reflected in scores on the Hurley scoring system and\n                      <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>\n                      . According to the\n                      <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>\n                      , patients achieved substantial improvement or complete remission. Clinically, all patients started to show signs of improvement within the first 3 months of therapy and continued to improve over the next 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study indicates that the combination of the anti\u2010inflammatory actions of colchicine and minocycline is effective in disease control in\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      . Colchicine emerged as a safe option for the maintenance of the obtained result.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.13428","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T23:16:47Z","timestamp":1483571807000},"page":"346-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Hidradenitis suppurativa treated with tetracycline in combination with colchicine: a prospective series of 20 patients"],"prefix":"10.1111","volume":"56","author":[{"given":"Kalliopi","family":"Armyra","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Andreas Sygros Skin Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anargyros","family":"Kouris","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Andreas Sygros Skin Hospital Athens 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