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Unmatched globin chains bind to the cytosolic surface of red blood cell membrane where they cause oxidative damage that might in part be responsible for membrane weakness. The deformability of red blood cells and hypercoagulable state in thalassemic patients have been incriminated in leg ulcer formation, as this might cause ischemia to the skin and consequently friability and ulceration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) gel is considered an advanced wound therapy for chronic and acute wounds. <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> gel consists of cytokines, growth factors, chemokines, and a fibrin scaffold derived from a patient's blood. In this study, we treated 100 thalassemic leg wounds using <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was wound size reduction in patients after 4 weeks of treatment. In wounds with 2\u20133.5\u00a0cm<jats:sup>2<\/jats:sup> surface area, complete closure happened after 12.5\u00a0weeks, 5\u201312\u00a0cm<jats:sup>2<\/jats:sup> wounds completely closed after 13.2\u00a0weeks, and finally, 4.5\u20136\u00a0cm<jats:sup>2<\/jats:sup> wounds healed completely after 14\u00a0weeks. None of the wounds reopened after 8\u00a0months of monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study will help extrapolation of the use of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> for at least thalassemic leg wound treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13443","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T05:36:45Z","timestamp":1474868205000},"page":"171-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of 100 chronic thalassemic leg wounds by plasma\u2010rich platelets"],"prefix":"10.1111","volume":"56","author":[{"given":"Hojjat","family":"Afradi","sequence":"first","affiliation":[{"name":"Iranian Blood Transfusion Organization Zafar Clinic Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassaman","family":"Saghaei","sequence":"additional","affiliation":[{"name":"Iranian Blood Transfusion Organization Zafar Clinic Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohre A.","family":"Kachoei","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid","family":"Babaei","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Teimourian","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Iran University of Medical Sciences Tehran Iran"},{"name":"Department of Infectious Diseases Pediatrics Infectious Diseases Research Center School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"179","article-title":"Peculiar elongated and sickle\u2010shaped red blood corpuscles in a case of severe anemia. 1910","volume":"74","author":"Herrick JB","year":"2001","journal-title":"Yale J Biol Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-193410000-00003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1001\/archinte.1974.00320160184017","article-title":"Leg ulceration in sickle cell anemia","volume":"133","author":"Serjeant GR","year":"1974","journal-title":"Arch Intern Med"},{"key":"e_1_2_6_5_1","first-page":"87","article-title":"Leg ulceration in sickle cell disease in Nigeria","volume":"31","author":"Akinyanju O","year":"1979","journal-title":"Trop Geogr Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.4.1403.1403"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.01.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920153"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200410000-00010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000204720"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198202000-00023"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80589-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2004.01.004"},{"key":"e_1_2_6_14_1","first-page":"273","article-title":"Autologous platelet lysate product versus placebo in patients with chronic leg ulcerations: a pilot study using a randomized, double\u2010blind, placebo\u2010controlled trial","volume":"16","author":"Weed B","year":"2004","journal-title":"Wounds"},{"key":"e_1_2_6_15_1","first-page":"515","article-title":"Autologous platelet\u2010derived wound healing factor promotes angiogenesis via alphavbeta3\u2010integrin expression in chronic wounds","volume":"6","author":"Herouy Y","year":"2000","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.3.483"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1051\/ject\/200537381","article-title":"Use of platelet gel and its effects on infection in cardiac surgery","volume":"37","author":"Trowbridge C","year":"2005","journal-title":"J Extra Corpor Technol"},{"key":"e_1_2_6_18_1","first-page":"36","article-title":"Chronic wounds treated with a physiologically relevant concentration of platelet\u2010rich plasma gel: a prospective case series","volume":"56","author":"Frykberg RG","year":"2010","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.33589\/20.1.0014","article-title":"Autologous platelet rich plasma (PRP): what do we know? 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