{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:12:56Z","timestamp":1782425576362,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus is a rare and fatal autoimmune disease for which the treatment options are limited. This study aimed to evaluate the efficacy of autologous peripheral hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">APHSCT<\/jats:styled-content>) for pemphigus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted <jats:styled-content style=\"fixed-case\">APHSCT<\/jats:styled-content> for 12 pemphigus patients (seven males and five females, mean age 23.8 years) with life\u2010threatening complications or who responded poorly to conventional therapy. Peripheral blood stem cells were mobilized with cyclophosphamide, granulocyte colony\u2010stimulating factor, and rituximab, and purified autologous <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34<jats:sup>+<\/jats:sup> stem cells were infused. Overall survival rate, progression\u2010free survival, and adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a mean follow\u2010up period of 80.3 months, overall survival and complete clinical remission rates were 92% (11\/12) and 75% (9\/12), respectively. Adverse effects included pyrexia, allergy, infection, and elevation of enzymes. Only one patient died of severe sepsis and multiple organ failure 2 months after <jats:styled-content style=\"fixed-case\">APHSCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall <jats:styled-content style=\"fixed-case\">APHSCT<\/jats:styled-content> is a promising therapeutic option for pemphigus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13461","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T07:07:29Z","timestamp":1484636849000},"page":"296-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Application of autologous hematopoietic stem cell transplantation for pemphigus"],"prefix":"10.1111","volume":"56","author":[{"given":"Menglei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebiao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifa","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingjiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.011"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12486"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12678"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312470729"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013458"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704679"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.01.070"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1872-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000714"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.02.022"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/465089"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102014\u2010208540"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1913-z"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.014"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.11.39"},{"key":"e_1_2_5_17_1","first-page":"817","article-title":"Pregnancy after stem cell transplantation","volume":"51","author":"Schechter T","year":"2005","journal-title":"Can Fam Physician"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12229"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2015.09.002"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.92667"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.10.034"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:35:48Z","timestamp":1695544548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,17]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/ijd.13461"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13461","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,17]]},"assertion":[{"value":"2016-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}