{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:48:47Z","timestamp":1766180927900},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor necrosis factor alpha (<jats:italic>TNF\u03b1<\/jats:italic>) gene \u2212238G\/A polymorphism (rs361525) is associated with psoriasis in several populations worldwide. To the best of our knowledge, there is no information about this polymorphism in Indian psoriatic patients. This study was undertaken to fill the gap in knowledge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control study involved 72 patients with psoriasis vulgaris (PsV) and 72 age and gender matched healthy individuals. <jats:italic>TNF\u03b1<\/jats:italic> \u2212238G\/A polymorphism was genotyped by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>TNF\u03b1<\/jats:italic> \u2212238A allele was 5 times commoner in PsV patients than in the control group (<jats:italic>P<\/jats:italic> = 4.1 \u00d7 10<jats:sup>\u22127<\/jats:sup>; odds ratio [OR] = 6.5 [0.95 CI: 2.9\u201314.6]). Distribution of the genotypes in the two groups showed statistically significant difference in dominant genetic model (<jats:italic>P<\/jats:italic> = 2.3 \u00d7 10<jats:sup>\u22127<\/jats:sup>) and not in recessive genetic model (<jats:italic>P<\/jats:italic> = 2.5 \u00d7 10<jats:sup>\u22121<\/jats:sup>). Odds ratio for the occurrence of \u2212238A genotype in PsV patients was 8.8 (0.95 CI: 3.5\u201320.2). The association showed no major difference when PsV patients were subgrouped into type I and type II categories and tested separately. Subgroup analysis on the basis of disease severity showed higher association with the moderate\u2010severe subgroup (<jats:italic>P<\/jats:italic> = 2.4 \u00d7 10<jats:sup>\u22129<\/jats:sup>, OR 15.4 [0.95 CI: 5.8\u201341.0]) than with mild subgroup (<jats:italic>P<\/jats:italic> = 1.3 \u00d7 10<jats:sup>\u22122<\/jats:sup>, OR 3.8 [0.95 CI: 1.3\u201310.9]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that <jats:italic>TNF\u03b1<\/jats:italic> gene \u2212238G\/A polymorphism increases the risk of developing psoriasis vulgaris among Indians. Also, the data show that severity and not the type affects the strength of association in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13482","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T07:07:09Z","timestamp":1484636829000},"page":"307-311","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tumor necrosis factor alpha gene promoter \u2212238G\/A polymorphism increases the risk of psoriasis vulgaris in Indian patients"],"prefix":"10.1111","volume":"56","author":[{"given":"Deepa","family":"Rajesh","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Molecular Genetics Sri Devaraj Urs Academy of Higher Education and Research Kolar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Gurumurthy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sri Devaraj Urs Medical College Kolar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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