{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:28:56Z","timestamp":1758400136551},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic actinic dermatitis (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) is a recurrent photosensitive dermatitis that occurs predominantly on sun\u2010exposed areas with unknown etiology. In severe cases, it may present with erythroderma, which is clinicopathologically analogous to cutaneous T\u2010cell lymphoma. Typically, inflammatory infiltrates in the skin lesions are mainly <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> reactive T cells. However, hematologic characteristics of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> have not been fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> ranging in age from 45 to 86 years (median, 64), including 17 males and three females (M\/F ratio, 5.7), were examined. All patients were phototested for <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> light. In addition, seven of the 20 patients with extensive eruption were also tested for visible light. All biopsy specimens were obtained from the <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> eruptions (<jats:italic>n<\/jats:italic> = 25 lesions). Histopathologic and immunohistochemical studies were performed. Furthermore, flow cytometric analysis was performed to determine the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\/8 ratio using peripheral blood mononuclear cells of 13 of the 20 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 11 of the 20 patients (55%), the eruption was localized to sun\u2010exposed areas. Skin\u2010infiltrating T cells were <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8\u2010dominant in the <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> eruption. Three patients (15%) showed erythroderma with a reduced <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\/8 ratio (median, 0.7) of peripheral mononuclear cells. As for treatment, eight of the 20 patients (40%) required oral cyclosporine in addition to topical therapies. Subsequently, the reduced <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\/8 ratio was normalized after treatment in two of the three patients with erythroderma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We considered that there appeared to be a relationship between the reduced <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\/8 ratio of circulating T cells (hematologic burden) and the affected area (skin burden).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13486","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T04:23:58Z","timestamp":1486527838000},"page":"540-546","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Phenotypic analysis of circulating T\u2010cell subset and its association with burden of skin disease in patients with chronic actinic dermatitis: a hematologic and clinicopathologic study of 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