{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:17:06Z","timestamp":1778894226418,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few treatment modalities are available for treating alopecia areata (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>) of the eyebrow. Due to the anatomical proximity of the eyebrows to the eyes, safety issues and side effects should always be taken into consideration when choosing the treatment modality. This study was designed to examine the efficacy of superficial cryotherapy on patients with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> of the eyebrow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Superficial cryotherapy was performed every other week on the right eyebrow (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\u2010treated) in a total of 20 patients who had been previously treated with diphenylcyclopropenone (<jats:styled-content style=\"fixed-case\">DPCP<\/jats:styled-content>) immunotherapy on the scalp. No specific treatment was performed on the left eyebrows as a control. The degree of eyebrow recovery was compared in 15 patients who continued to receive more than 10 superficial cryotherapy treatments (5\u00a0months of treatment) on their right eyebrow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hair density was significantly increased on both treated and control eyebrows after 5\u00a0months of treatment compared with the pretreatment density; moreover, the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\u2010treated eyebrows exhibited a significantly greater increase in density than the control eyebrows. Although hair thickness in the control eyebrows did not change significantly over the treatment period, hair thickness of the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\u2010treated eyebrows showed a statistically significant increase at months 3 and 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Superficial cryotherapy is associated with minimal to no adverse events and exhibits high compliance and relatively good efficacy. Thus, this treatment is an important additional option for patients with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> of the eyebrow.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13533","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T10:07:50Z","timestamp":1484302070000},"page":"184-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of superficial cryotherapy on the eyebrows of patients with alopecia universalis also treated with contact immunotherapy on the scalp: a prospective, split\u2010face comparative study"],"prefix":"10.1111","volume":"56","author":[{"given":"Sung Jay","family":"Choe","sequence":"first","affiliation":[{"name":"Department of Dermatology and Institute of Hair and Cosmetic Medicine Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won\u2010Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Institute of Hair and Cosmetic Medicine Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103909"},{"issue":"3","key":"e_1_2_5_3_1","first-page":"S31","article-title":"Therapeutic approach to alopecia areata","volume":"3","author":"Wiseman MC","year":"1999","journal-title":"J Cutan Med 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