{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:42:01Z","timestamp":1790775721156,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"K\u0131r\u0131kkale University Scientific Research Projects Coordination Unit"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the etiopathogenesis of vitiligo, the role of suppressor cytokines, such as transforming growth factor\u2010<jats:italic>\u03b2<\/jats:italic> (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>) and interleukin\u201010 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010), associated with regulatory T\u2010cells (Treg) is not completely known. In this study, the role of Treg\u2010cell functions in the skin of patients with nonsegmental vitiligo was investigated. Lesional and nonlesional skin samples from 30 adult volunteers ranging in age from 18 to 36 years with nonsegmental vitiligo were compared with normal skin area excision specimens of 30 benign melanocytic nevus cases as controls. All samples were evaluated staining for forkhead box P3 (Foxp3), <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 using the standardized streptavidin\u2013biotin immunoperoxidase immunohistochemistry method. Foxp3 expression was lower in lesional vitiligo skin specimens compared to controls; it was also lower in lesional vitiligo specimens than nonlesional vitiligo specimens. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 levels were lower in lesional vitiligo specimens compared to the controls, whereas <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 expression was significantly lower in lesional specimens compared with nonlesional specimens. <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic> expression was higher in both lesional and nonlesional skin specimens of patients with vitiligo compared to controls. <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic> expression was lower in lesional skin specimens than nonlesional skin specimens. In addition, there was no significant correlation between Foxp3 expression with <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 expressions in lesional skin specimens in the vitiligo group. In this study, results supporting the contribution of Treg cells and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 deficiency to the autoimmune process were obtained. Therefore, future studies are necessary to demonstrate the definitive role of Treg\u2010cell functions in the etiopathogenesis of vitiligo.<\/jats:p>","DOI":"10.1111\/ijd.13564","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T11:19:28Z","timestamp":1488367168000},"page":"581-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Regulatory T\u2010cell cytokines in patients with nonsegmental vitiligo"],"prefix":"10.1111","volume":"56","author":[{"given":"Mehtap","family":"Kidir","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine University of Kirikkale  Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse A.","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine University of Kirikkale  Kirikkale 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