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Resulting from a defect in enzymes in the porphyria pathway, <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> has been linked to several conditions. Recent studies have demonstrated a change in thinking regarding the human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) and development of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>. The exacerbation of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> with contraction of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> is now believed to result from coinfection from the hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>). Blistering of sun\u2010exposed skin, a classic presenting sign of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>, is not exclusive to the condition. Cutaneous findings must also trigger physicians to consider additional types of porphyrias, such as variegate porphyria. The diagnosis of pseudoporphyria, which does not result from enzymatic absence, must be considered in patients with photosensitivity and cutaneous bullae. Recent health food trends, such as chlorophyll, have been linked to pseudoporphyria. <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> is a serious condition in which accurate diagnosis is necessary for appropriate management.<\/jats:p>","DOI":"10.1111\/ijd.13580","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T15:56:21Z","timestamp":1490111781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Porphyria cutanea tarda: an intriguing genetic disease and marker"],"prefix":"10.1111","volume":"56","author":[{"given":"Nancy S.","family":"Handler","sequence":"first","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Z.","family":"Handler","sequence":"additional","affiliation":[{"name":"Dermatology Rutgers New Jersey Medical School Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Stephany","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn A.","family":"Handler","sequence":"additional","affiliation":[{"name":"Dermatology Rutgers New Jersey Medical School Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Dermatology Rutgers New Jersey Medical School Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_28_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5479.65"},{"key":"e_1_2_28_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66991-7"},{"key":"e_1_2_28_4_1","volume-title":"Heme, Chlorophyll, And Bilins: Methods And Protocols","author":"Smith AG","year":"2002"},{"key":"e_1_2_28_5_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1182\/asheducation.V2012.1.19.3795678","article-title":"The porphyrias: advances in diagnosis and treatment","volume":"2012","author":"Balwani M","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"e_1_2_28_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00061"},{"key":"e_1_2_28_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi342"},{"key":"e_1_2_28_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13169"},{"key":"e_1_2_28_9_1","first-page":"63","article-title":"The cutaneous porphyrias","volume":"9","author":"Elder GH","year":"1990","journal-title":"Semin Dermatol"},{"key":"e_1_2_28_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61925-5"},{"key":"e_1_2_28_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960173"},{"key":"e_1_2_28_12_1","volume-title":"Fitzpatrick's Dermatology In General Medicine","author":"Goldsmith LA","year":"2012"},{"key":"e_1_2_28_13_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.117432"},{"key":"e_1_2_28_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.03.001"},{"key":"e_1_2_28_15_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.13.0649"},{"key":"e_1_2_28_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007142"},{"key":"e_1_2_28_17_1","volume-title":"GeneReviews(R)","author":"Liu LU","year":"1993"},{"key":"e_1_2_28_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91615-9"},{"key":"e_1_2_28_19_1","first-page":"712","article-title":"Uroporphyrinogen decarboxylase: complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria","volume":"58","author":"Moran\u2010Jimenez MJ","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_28_20_1","volume-title":"The 5\u2010Minute Pediatric Consult","author":"Schwartz MW","year":"2012"},{"key":"e_1_2_28_21_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.111338"},{"key":"e_1_2_28_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540100500604"},{"key":"e_1_2_28_23_1","doi-asserted-by":"publisher","DOI":"10.4065\/76.5.488"},{"key":"e_1_2_28_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.07.002"},{"key":"e_1_2_28_25_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2014.40662"},{"key":"e_1_2_28_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02113.x"},{"key":"e_1_2_28_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181d50928"},{"key":"e_1_2_28_28_1","unstructured":"FryeRE PhD.Cutaneous Porphyria Workup.2014. 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