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This paper aims to review all recent available data on pediatric PG. A systematic review of the literature was conducted using Embase, Medline, and Cochrane databases. A total of 132 articles were included in the review. The most commonly reported underlying diseases in pediatric PG are inflammatory bowel diseases followed by hematologic disorders, vasculitis, immune deficiencies and Pyogenic Arthritis, Pyoderma gangrenosum and Acne (PAPA) syndrome. More than half of the cases occur with no underlying disease. The most frequently reported clinical presentation is multiple disseminated ulcers. Treatment should be tailored according to the underlying etiology. It includes systemic steroids, corticosteroid sparing agents such as dapsone and cyclosporine, and\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010alpha inhibitors such as adalimumab and infliximab. Response to treatment is high with cure rates reaching 90%. A high index of suspicion and a thorough workup are mandatory in the management of pediatric PG.\n                  <\/jats:p>","DOI":"10.1111\/ijd.13584","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T23:22:47Z","timestamp":1487892167000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Pediatric pyoderma gangrenosum: a systematic review and update"],"prefix":"10.1111","volume":"56","author":[{"given":"Elio","family":"Kechichian","sequence":"first","affiliation":[{"name":"Department of Dermatology Hotel Dieu de France University Hospital Beirut Lebanon"},{"name":"Faculty of Medicine Saint Joseph University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Haber","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hotel Dieu de France University Hospital Beirut Lebanon"},{"name":"Faculty of 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