{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:51Z","timestamp":1787509311136,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although with a lower incidence than in other geographic areas, leishmaniasis is also endemic on the European Mediterranean coast. However, there are few studies on the clinical features of cutaneous lesions of leishmaniasis in Europe. Our objective was to review the clinical features of cutaneous leishmanial lesions in our European Mediterranean population in the last 30 years and compare the clinical features of immunosuppressed and nonimmunosuppressed patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical features of cutaneous lesions of leishmaniasis diagnosed between 1987 and 2016 at Bellvitge Hospital in Barcelona, Spain, were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cutaneous lesions of leishmaniasis were diagnosed in 68 patients (40 male and 28 female, mean age 53.60 years,\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      19.68). Thirteen patients were immunosuppressed because of acquired immune deficiency syndrome (AIDS) (7), renal transplantation (1), lymphoma (1), and anti\u2010\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      agents (4). Our immunosuppressed patients had more lesions (3.33 vs. 1.80,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.021), with greater maximum diameter (33.00 vs. 13.33 mm,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001), and their lesions were more frequently disseminated (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.008). Visceral leishmaniasis was observed only in immunosuppressed patients. Patients treated with anti\u2010\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      drugs developed unusually large skin lesions with crusted, eroded surfaces and without a tendency to spontaneous remission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      With the widespread use of anti\u2010\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      agents, an increase in severe forms of leishmaniasis can be expected. The development of persistent, crusted, or eroded erythematous\u2010brownish plaques in patients treated with anti\u2010\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      drugs who live or had traveled to endemic areas of\n                      <jats:italic>Leishmania<\/jats:italic>\n                      infection warrants consideration of a diagnosis of cutaneous leishmaniasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.13588","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T06:21:12Z","timestamp":1488349272000},"page":"750-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evolution of cutaneous leishmaniasis in the last 30 years in a tertiary hospital of the European Mediterranean coast"],"prefix":"10.1111","volume":"56","author":[{"given":"Joaquim","family":"Marcoval","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitari de Bellvitge IDIBELL University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Pen\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari de Bellvitge IDIBELL University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0114-z"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70209-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003021"},{"key":"e_1_2_6_5_1","article-title":"Cutaneous leishmaniasis associated with anti\u2010TNF\u2010\u03b1 drugs: an emerging disease","author":"Marcoval J","journal-title":"Clin Exp Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.6.2097"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370238"},{"key":"e_1_2_6_8_1","first-page":"310","article-title":"Cutaneous leishmaniasis: 20 years\u2019 experience in a Spanish tertiary care hospital","volume":"106","author":"Giavedoni P","year":"2015","journal-title":"ActasDermosifiliogr"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.051"},{"key":"e_1_2_6_10_1","first-page":"69","article-title":"Canine leishmaniosis \u2010 an emerging disease","volume":"61","author":"Kaszak I","year":"2015","journal-title":"Ann Parasitol."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1407.071589"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:51:13Z","timestamp":1695552673000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/ijd.13588"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13588","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"2016-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}