{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:29:43Z","timestamp":1780921783919,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The use of potassium iodide (KI<\/jats:styled-content>) to treat palmoplantar pustulosis (PPP<\/jats:styled-content>) and pustulotic arthro\u2010osteitis (PAO<\/jats:styled-content>) has not previously been reported. Here, we report the first successful treatment of PPP<\/jats:styled-content> and PAO<\/jats:styled-content> with KI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Patient and Methods<\/jats:title>Among 25 patients with PPP<\/jats:styled-content>, seven had an associated PAO<\/jats:styled-content>. All patients were administered 900\u00a0mg KI<\/jats:styled-content> three times per day for 3\u00a0months. Overall, 12 patients received this medical treatment for the first time or had >6\u00a0months interval since the last therapy for PPP<\/jats:styled-content>. The other 13 patients who were nonresponsive to tetracycline for >3\u00a0months prior to KI<\/jats:styled-content> treatment were treated with a combination of KI<\/jats:styled-content> and tetracycline. All seven patients with PAO<\/jats:styled-content> were included in the tetracycline and KI<\/jats:styled-content>\u2010treated group.<\/jats:p><\/jats:sec>Results<\/jats:title>More than 70% of patients demonstrated complete clearance or \u226550% improvement in palmoplantar pustular psoriasis area and severity index (PPPASI<\/jats:styled-content>) from baseline. In the group with <50% improvement in PPPASI<\/jats:styled-content> from baseline, all except one patient were smokers. In the KI<\/jats:styled-content> with tetracycline treatment group, approximately 80% demonstrated improvement. At the end of 3\u00a0months, there was remission of arthralgia in five out of seven PPP<\/jats:styled-content> patients with PAO<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Treatment with KI<\/jats:styled-content> and\/or its combination with tetracycline may be a useful treatment for PPP<\/jats:styled-content>\/PAO<\/jats:styled-content>. Smoking may affect the effectiveness of these treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13608","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T12:36:29Z","timestamp":1490877389000},"page":"889-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Palmoplantar pustulosis and pustulotic arthro\u2010osteitis treatment with potassium iodide and tetracycline, a novel remedy with an old drug: a review of 25 patients"],"prefix":"10.1111","volume":"56","author":[{"given":"Shujiro","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University School of Medicine Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Shimaoka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University School of Medicine Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University School of Medicine Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hatamochi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University School of Medicine Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.01219.x"},{"key":"e_1_2_5_3_1","first-page":"854","article-title":"Palmoplantar pustulosis with arthro\u2010osteitis: successful treatment with etanercept and acitretin","volume":"23","author":"Antoniou C","year":"2009","journal-title":"JEADV"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20132377"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107247"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.07.016"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04411.x"},{"key":"e_1_2_5_8_1","first-page":"7522","volume-title":"Rook's. 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