{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:17Z","timestamp":1787014337132,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The association of specific skin disorders with diabetes mellitus (\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    ) has been well established. Current literature suggests that approximately 30\u201391% of patients with diabetes will experience at least one cutaneous manifestation of this systemic disease in their lifetime. To date, there are limited articles summarizing the link between necrobiosis lipoidica diabeticorum (\n                    <jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content>\n                    ) prognosis and glycemic control in patients with diabetes. The objective of the study is to summarize and appraise the available evidence assessing the relationship between glycemic control and\n                    <jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content>\n                    . A literature search was conducted based on\n                    <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                    (1946\u20132015),\n                    <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                    (1980\u20132015), Google Scholar, and PubMed for publications that described the results of diabetes control and\n                    <jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content>\n                    . Further studies were identified from bibliographies of all relevant studies, gray literature, and annual scientific assemblies. All studies investigating the relationship between\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    (type 1 and type 2) management and\n                    <jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content>\n                    were included. Two reviewers independently extracted data including demographics, type of diabetes management measures (glucose, HbA1c, insulin), comorbidities, and outcome. A total of 622 studies were identified, and 10 studies met the inclusion and exclusion criteria: two case series and eight case reports. Of the 24 patients with\n                    <jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content>\n                    , 13 patients reported resolution of\n                    <jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content>\n                    after implementing various methods of glycemic control (diabetic diet consisting of 1600 kcal\/day [1 patient], insulin regimen [3 patients], and pancreatic transplantation [9 patients]). Glycemic control may have a role in influencing the prognosis of necrobiosis lipoidica in patients with diabetes; however, there is currently insufficient evidence to support or refute this claim.\n                  <\/jats:p>","DOI":"10.1111\/ijd.13610","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T06:54:36Z","timestamp":1498460076000},"page":"1319-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus"],"prefix":"10.1111","volume":"56","author":[{"given":"Bhavik D.","family":"Mistry","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of British Columbia Vancouver British Columbia 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