{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:37:08Z","timestamp":1761129428882},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liver enzymes appear to be involved in oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>), but it is not known whether the elevation develops concomitantly with exacerbations of disease. We compared the levels of serum hepatic aspartate (<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>) and alanine (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) aminotransferases as markers of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> exacerbation in patients with chronic hepatitis C from those with chronic liver disorders, seronegative for hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 71 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, (48 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seropositive and 23 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seronegative with chronic liver diseases) measuring <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>. Association of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection status with serum aminotransferase levels in relation to several types of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, exacerbations, and clinical score was studied by means of logistic and linear regression (correcting for age and sex).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 476 patients screened, 71 were eligible for the study. Patients in the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seropositive group had more elevation of <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> levels (mean level, 51.0 U\/l; normal level, &lt;45) than patients in the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seronegative group (mean level, 47.5 U\/l). Mean serum <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> exceeded the upper limit of the normal range in 33 of 48 (68.8%) in the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibody\u2010positive group and in 9 of 23 (39.5%) in the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibody\u2010negative group. Exacerbations of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> were more frequent in the high\u2010level <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> group, while <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> status group played a minor role.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, mild elevation in aminotransferase levels was more common in patients infected with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> concentrations were elevated in association with exacerbation of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13626","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T05:52:41Z","timestamp":1493963561000},"page":"842-849","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exacerbations of oral lichen planus and elevated levels of aminotransferases"],"prefix":"10.1111","volume":"56","author":[{"given":"Gian P.","family":"Bombeccari","sequence":"first","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Unit of Oral Pathology and Medicine Ospedale Maggiore Policlinico Fondazione Ca\u2019 Granda IRCCS University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Tettamanti","sequence":"additional","affiliation":[{"name":"Laboratory of Geriatric Neuropsychiatry Istituto di Ricerche Farmacologiche Mario Negri Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pallotti","sequence":"additional","affiliation":[{"name":"Unit of Anatomical Pathology Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Spadari","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Unit of Oral Pathology and Medicine Ospedale Maggiore Policlinico Fondazione Ca\u2019 Granda IRCCS University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo B.","family":"Giann\u00ec","sequence":"additional","affiliation":[{"name":"Maxillo\u2010Facial and Odontostomatology Unit (Head: prof. 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