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The prototype is \u201cxanthelasma palpebrarum\u201d (<jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>) that is localized only to the eyelids and may be associated with hyperlipidemia. On the other hand, different types of normolipemic disorders may also cause xanthomatous eyelid lesions. Among these, Langerhans cell histiocytosis, diffuse normolipemic xanthoma, and non\u2010Langerhans cell histiocytoses (papular xanthoma, juvenile xanthogranuloma, xanthoma disseminatum, adult\u2010onset xanthogranuloma, adult\u2010onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, Erdheim\u2010Chester disease, Rosai\u2010Dorfman disease, and reticulohistiocytosis) can be listed. The eyelid findings of this heterogeneous group of disorders are challenging to differentiate from each other due to common clinical aspects that may even sometimes mimic <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>. Nodularity, induration, ulceration, diffuse eyelid involvement, and extension from eyelids to the neighboring skin may represent the clinical features of xanthomatous lesions other than <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>. It is necessary to obtain a thorough history and exclude <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content> and then perform detailed dermatological and systemic examination, biopsy for histopathologic confirmation, and appropriate specific imaging screens. As some of the conditions may be associated with other systemic disorders, especially malignancies, the differentiation of xanthomatous eyelid lesions has a critical importance, and clinical signs can be guiding.<\/jats:p>","DOI":"10.1111\/ijd.13637","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T05:46:28Z","timestamp":1494654388000},"page":"981-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The clinical spectrum of xanthomatous lesions of the eyelids"],"prefix":"10.1111","volume":"56","author":[{"given":"Can","family":"Baykal","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Algun","family":"Polat Ekinci","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtulus D.","family":"Yazganoglu","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesimi","family":"Buyukbabani","sequence":"additional","affiliation":[{"name":"Pathology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200210000-00016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/932863"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70023-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5070\/D329G492HT","article-title":"Normolipemic papular xanthoma with xanthelasma","volume":"12","author":"Singla A","year":"2006","journal-title":"Dermatol Online J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5497"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00391.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-008-0615-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000555"},{"key":"e_1_2_8_10_1","first-page":"720","article-title":"Juvenile xanthogranuloma developing after treatment of Langerhans cell histiocytosis: case report and literature review","volume":"5","author":"Strehl JD","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00842.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338189"},{"key":"e_1_2_8_13_1","volume-title":"Text Atlas of Histiocytic Syndromes","author":"Caputo R","year":"1998"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70321-4"},{"key":"e_1_2_8_15_1","first-page":"762","article-title":"Yellow changes of the skin: a quiz. 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