{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:10:45Z","timestamp":1777414245231,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Second hematologic cancers in patients with chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL<\/jats:styled-content>) are well documented and include Hodgkin lymphoma, therapy\u2010related acute myeloid leukemia\/myelodysplastic syndromes, and transformation to diffuse large B\u2010cell lymphoma. Although cutaneous T\u2010cell lymphoma (CTCL<\/jats:styled-content>) has been reported in patients with CLL<\/jats:styled-content>, the incidence and comparison to expected rates are unknown. We evaluated the incidence of CTCL<\/jats:styled-content> among patients with CLL<\/jats:styled-content> or other non\u2010Hodgkin lymphoma (NHL<\/jats:styled-content>) subtypes using data from the Surveillance, Epidemiology, and End Results (SEER<\/jats:styled-content>) Program.<\/jats:p><\/jats:sec>Methods<\/jats:title>We searched the SEER<\/jats:styled-content> 13 registries for patients with a diagnosis of CLL<\/jats:styled-content> and NHL<\/jats:styled-content> between 1992 and 2008. Among patients identified, we evaluated the incidence of CTCL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 31,286 patients with CLL<\/jats:styled-content>, the incidence of CTCL<\/jats:styled-content> was not significantly higher in men than women: 104.2 (95% CI<\/jats:styled-content>, 50.0\u2013191.8) and 28.1 (95% CI<\/jats:styled-content>, 3.4\u2013101.3) per 1,000,000 person\u2010years, respectively (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.06). Among 97,691 patients with NHL<\/jats:styled-content>, the incidence of CTCL<\/jats:styled-content> was similar in men and women (97.9 [95% CI<\/jats:styled-content>, 62.0\u2013146.9] and 92.0 [95% CI<\/jats:styled-content>, 56.2\u2013142.1] per 1,000,000 person\u2010years, respectively; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.84). The incidence of CTCL<\/jats:styled-content> among males with CLL<\/jats:styled-content> (standardized incidence ratio [SIR], 3.0 [95% CI<\/jats:styled-content>, 1.4\u20135.5]), males with NHL<\/jats:styled-content> (SIR<\/jats:styled-content>, 3.7 [95% CI<\/jats:styled-content>, 2.3\u20135.5]), and females with NHL<\/jats:styled-content> (SIR<\/jats:styled-content>, 5.9 [95% CI<\/jats:styled-content>, 3.6\u20139.1]) was significantly higher than expected in the general population (all P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The risk of CTCL<\/jats:styled-content> is greater in men with CLL<\/jats:styled-content> than in the general population. In patients with NHL<\/jats:styled-content>, both men and women are at greater risk for CTCL<\/jats:styled-content> than in the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13653","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T13:05:32Z","timestamp":1499432732000},"page":"1125-1129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk of cutaneous T\u2010cell lymphoma in patients with chronic lymphocytic leukemia and other subtypes of non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"56","author":[{"given":"Timothy W.","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN 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