{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:08:09Z","timestamp":1781917689637,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007338","name":"All-India Institute of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical morphology of anogenital warts may vary from flat, filiform, papular, or verrucous to giant condyloma acuminatum. Clinically atypical\u2010looking genital warts may alarm the clinician because of their suspected malignant potential, which may cause anxiety, often leading to aggressive interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study if clinically atypical\u2010looking anogenital warts are more likely to be premalignant or malignant as compared to typical warts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Data of 41 (37 males, 4 females) patients with anogenital warts was retrospectively analyzed. After a detailed literature review and in\u2010house discussions, criteria for anogenital warts with typical and atypical clinical morphology were defined. Clinical photographs were independently reviewed by three dermatologists, and human papillomavirus (HPV) genotyping results, histological evaluation, and immunohistochemical analysis for p53 expression were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen (36.6%) anogenital warts were classified as atypical by at least two of three blinded dermatologists. The histological examination showed mitotic figures in 31\/41 (75.6%) specimens, dysplasia in 14\/41 (44.1%) specimens, and p53 positivity in 34\/41 (82.9%) specimens. There was no significant difference in the high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotyping (<jats:italic>P<\/jats:italic> = 0.67), frequency of dysplastic changes on histology (<jats:italic>P<\/jats:italic> = 0.19), and immunohistochemistry with p53 (<jats:italic>P<\/jats:italic> = 0.08) between clinically typical and atypical\u2010appearing anogenital warts. Similarly, no significant difference was found in the frequency of dysplastic changes (<jats:italic>P<\/jats:italic> = 0.67) or p53 expressions (<jats:italic>P<\/jats:italic> =0.41) based on the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The atypical clinical morphology of anogenital warts may not be a marker of increased malignant potential. High\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotypes do not have a statistically significant association with dysplasia or positive immunohistochemistry with p53.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13711","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T10:55:38Z","timestamp":1500980138000},"page":"1017-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Atypical morphology of anogenital warts is not a marker of atypical histology or of infection to the high\u2010risk human papillomavirus genotypes"],"prefix":"10.1111","volume":"56","author":[{"given":"Pankaj","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Bhari","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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